Title:
新規な陽イオン性ポリホスファゼン化合物、ポリホスファゼン−薬物コンジュゲート化合物およびその製造方法
Document Type and Number:
Japanese Patent JP6867084
Kind Code:
B2
Abstract:
The present invention relates to a new class of cationic linear polyphosphazenes bearing as side groups a hydrophilic poly(ethylene glycol) and a spacer group selected from the group consisting of lysine, oligopeptides containing lysine, amino-ethanol, amino-propanol, amino-butanol, amino-pentanol and amino-hexanol, and the polyphosphazene-drug conjugates comprising hydrophobic anticancer drugs by covalent bonding and the preparation methods thereof. The present polyphosphazene-drug conjugates exhibit outstanding tumor selectivity and low toxicity.
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Inventors:
SOHN, Youn Soo
Jun, Yong Jo
Avazi, Prakash Gouda
Jun, Yong Jo
Avazi, Prakash Gouda
Application Number:
JP2019045513A
Publication Date:
April 28, 2021
Filing Date:
March 13, 2019
Export Citation:
Assignee:
CNPHARM CO., LTD.
International Classes:
A61K47/59; A61K31/282; A61K31/337; A61K47/65; A61P35/00; C08G79/025; C08G81/00
Domestic Patent References:
| JP6659021B2 |
Foreign References:
| US20130324490 | ||||
| US20070292384 | ||||
| WO2013016696A1 |
Other References:
Bioorganic & Medicinal Chemistry Letters,2007年,17,2975-2978
Attorney, Agent or Firm:
Ikeda adult
Junichiro Sakamaki
Masakazu Noda
Junichiro Sakamaki
Masakazu Noda