Title:
新規なセファロタキサン誘導体およびそれらの製造法
Document Type and Number:
Japanese Patent JP4942871
Kind Code:
B2
Abstract:
The present invention concerns a new general process for asymmetric hemisynthesis of harringtonines and their analogs, that are alkaloids used in chemotherapy. This process comprises direct esterification of a natural cephalotaxine with an acylating compound constituted of a side chain precursor which backbone and functionalization are entirely preformed. The invention also concerns a natural, synthetic or semi-synthetic harringtonines including their tautomeric forms and their salts of the following formula: wherein n=2 (i.e. harringtonine) or n=3 (i.e. homoharringtonine), in which the total content of impurities, possibly including enantiomeric forms, is lower than 1%, and/or the content of the major impurity is lower than 0.9%, and/or the chromatographic assay exhibits a harringtonines content higher than 97.5%.
Inventors:
Jean-Pierre, Robin
Julie, robin
Silvie, Caboro
Ludovic, shobia
Sandra, Charbonnel
Robert, Dahl
Jill, Dujardin
Florence, Fournier
Christel, Gilet
Laurent, Girodie
Laurence, Mubul
Sandrine, Pute
Silvie, Luau
Julie, robin
Silvie, Caboro
Ludovic, shobia
Sandra, Charbonnel
Robert, Dahl
Jill, Dujardin
Florence, Fournier
Christel, Gilet
Laurent, Girodie
Laurence, Mubul
Sandrine, Pute
Silvie, Luau
Application Number:
JP2000537877A
Publication Date:
May 30, 2012
Filing Date:
March 17, 1999
Export Citation:
Assignee:
CHEMGENEX PHARMACEUTICALS LTD.
International Classes:
C07D487/04; A61K31/55; A61P35/00; C07C57/13; C07C59/42; C07C59/48; C07C69/732; C07D303/48; C07D305/08; C07D309/08; C07D453/04; C07D491/147; C07D491/20; C07D493/10
Domestic Patent References:
| JPS5764695A | 1982-04-19 | |||
| JP2045102194A |
Attorney, Agent or Firm:
Kenji Yoshitake
Hirohito Katsunuma
Yukitaka Nakamura
Konno Akio
Noritaka Yokota
Hirohito Katsunuma
Yukitaka Nakamura
Konno Akio
Noritaka Yokota