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Title:
NEW COMPOUND, ITS PRODUCTION AND PHARMACEUTICAL COMPOSITION CONTAINING IT
Document Type and Number:
Japanese Patent JPH03151389
Kind Code:
A
Abstract:

NEW MATERIAL: A compound of formula I [X is H or NHR1 (R1 is H or an amino-protecting group); R is (substd.) spiro-fused or bridged bicyclic group optionally having O, N or S].

EXAMPLE: 6β[Z-[2-(2-Aminothiazol4-yl)-3(bicyclo[2,2,1]hept2-yl)]propeneamido]- penicillanic acid.

USE: Antibacterial agents which are highly stable to β-lactamase.

PROCESS: A compound of formula II (the amino group may be substituted by an acyl-forming group; R3 is H or a carboxyl-blocking group) is treated with an acylating agent derived from an acid of formula III (Y is formula IV).


Inventors:
ROJIYAA JIYON PONSUFUOODO
ANDORUU BARENCHIN SUTACHIYURUS
Application Number:
JP26824490A
Publication Date:
June 27, 1991
Filing Date:
October 05, 1990
Export Citation:
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Assignee:
SMITHKLINE BEECHAM PLC
International Classes:
C07D499/58; A61K31/43; A61P31/04; C07D499/00; C07D499/46; C07D519/06; (IPC1-7): A61K31/43; C07D277/593; C07D499/58; C07D519/00
Attorney, Agent or Firm:
Masamitsu Akizawa (1 person outside)