新規化合物

Japanese Patent JP5291623

B2

Pyridine-piperazine-phenyl derivatives (I) or their enantiomers, diastereomers or salts, preferably salts with organic or inorganic acid or base, are new. Pyridin-piperazin-phenyl derivative (I) of formula (R 5>-A-R 4>-B 1>-R 3>-A-D-Y 1>-N(R 2>)-SO 2-R 1>) or their enantiomers, diastereomers or salts, preferably salts with organic or inorganic acid or base, are new. A : a bond or 1-4C alkylene; B 1> : a bond, 1-3C alkylene, -O- or -C(O)-; D : amine group of formula (-N(R 2>)-C(O)-) or (-C(O)-N(R 2>)-); Y 1> : 1-4C-alkylene optionally substituted by R 2>, where a methylene group can be replaced in addition by Y 2>; Y 2> : -O-, -S-, -S(O)-, -N(R 2>)-, -N(R 2>)-C(O)-, -C(O)-N(R 2>)-, -C(O)-, -CH(aryl)- or -S(O) 2-; R 1> : 3-7C-cycloalkyl- or aryl-, heteroaryl- or aryl-1-3C-alkyl- (all substituted with 1-4 R1a); R 2> : H or 1-3C-alkyl, where each methylene group is substituted with up to two F and each methyl group is replaced with up to 3 F; R 3> : arylene, heteroarylene, saturated 4-7-membered heterocyclic ring, unsaturated 5-7 membered heterocyclic ring (all substituted with 1 or 2 R3a) or 1-6C-alkylene; R 4> : arylene, heteroarylene, saturated 4-7-membered heterocyclic ring, unsaturated 5-7 membered heterocyclic ring (all substituted with 1 or 2 R4a), -O-, -C(O)O-, -C(O)NR 2>-, -NR 2>-, -NR 2>-NR 2>-, -3-7C-cycloalkylene- or -1-6C-alkylene-; R 5> : heteroaryl, 4-7 membered saturated heterocyclic ring (both substituted with 1 or 2 R5a), H, 1-8C alkyl, 3-7C-cycloalkyl (optionally substituted with 1-3C alkyl), H 2N-, 1-4C-alkyl-NH-, (1-4C-alkyl) 2N- or H 2N-C(O)-; and R1a, R3a, R4a, R5a : H, F, Cl, Br, I, 1-3C-alkyl-, HO-, 1-3C-alkyl-O- or 1-3C-alkyl-O-2-4C-alkylene-O-. An independent claim is included for pyridin-piperazin-phenyl salts with inorganic or organic acids or bases. ACTIVITY : Analgesic; Antimigraine; Neuroprotective; Dermatological; Cerebroprotective; Vasotropic; Antiallergic; Immunosuppressive; Gastrointestinal-Gen; Respiratory-Gen; Antiasthmatic; Antiinflammatory; Antiarthritic; Osteopathic. MECHANISM OF ACTION : None given.

Kaufmann Hefner Iris
Howell norbert
Walter liner
Abel Heiner
Dorts Henry
Cecí Angelo
Schuler Mets Anette
Connectsky ingo

JP2009525021A

September 18, 2013

August 14, 2007

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Boehringer Ingelheim International GmbH

C07D209/44; A61K31/18; A61K31/341; A61K31/40; A61K31/4035; A61K31/404; A61K31/4164; A61K31/4168; A61K31/417; A61K31/4184; A61K31/4196; A61K31/422; A61K31/426; A61K31/427; A61K31/437; A61K31/438; A61K31/44; A61K31/4418; A61K31/4427; A61K31/4439; A61K31/445; A61K31/451; A61K31/454; A61K31/4545; A61K31/47; A61K31/472; A61K31/4725; A61K31/495; A61K31/496; A61K31/501; A61K31/502; A61K31/505; A61K31/5375; A61K31/5377; A61K31/55; A61K31/551; A61P25/04; A61P25/06; A61P29/00; C07D211/26; C07D211/56; C07D211/58; C07D213/40; C07D215/38; C07D223/12; C07D223/16; C07D235/04; C07D235/18; C07D241/04; C07D295/10; C07D295/12; C07D295/18; C07D401/04; C07D401/06; C07D471/04; C07D471/10

JP2004534729A
JP2005535613A
JP10506122A
JP2006516132A

WO2006048209A1
WO2006071775A2
WO2006036664A1
WO2006035967A1
WO2001037826A1
US20060178360

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Koichi Tsujii
Sadao Kumakura
Atsushi Hakoda
Kenji Asai
Kazuo Yamazaki
Satsuki Ichikawa
Yasushi Sasaki

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