新規化合物

Japanese Patent JP7261264

B2

The present invention relates to novel compounds and methods for the manufacture of inhibitors of deubiquitylating enzymes (DUBs). In particular, the invention relates to the inhibition of ubiquitin C-terminal hydrolase LI (UCHL1). The invention further relates to the use of DUB inhibitors in the treatment of cancer and other indications. Compounds of the invention include compounds having the formula (I)or a pharmaceutically acceptable salt thereof, wherein R₁ to R₈ are as defined herein.

WO/2006/105979	SULFONYLPYRROLES AS HISTONE DEACETYLASE INHIBITORS
WO/2013/013817	SUBSTITUTED HETEROCYCLIC AZA DERIVATIVES
JPS54141781	1-(MALEIMIDOACYLOXY)-2(1H)-PYRIDONE COMPOUND

Allison Jones
Mark Ian Kemp
Martin Lee Stockley
Carl Richard Gibson
Gavin Alistair Whitlock
Andrew Madin

JP2021092454A

April 19, 2023

June 01, 2021

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Mission Therapeutics Limited

C07D401/12; A61K31/4155; A61K31/416; A61K31/4178; A61K31/4184; A61K31/4192; A61K31/422; A61K31/427; A61K31/428; A61K31/433; A61K31/437; A61K31/4375; A61K31/4439; A61K31/444; A61K31/454; A61K31/4545; A61K31/4725; A61K31/496; A61K31/497; A61K31/4985; A61K31/501; A61K31/506; A61K31/519; A61K31/5377; A61K31/551; A61P3/00; A61P11/00; A61P25/00; A61P29/00; A61P31/04; A61P31/12; A61P35/00; C07D401/14; C07D403/12; C07D403/14; C07D405/14; C07D413/12; C07D413/14; C07D417/12; C07D417/14; C07D471/04; C07D487/04

JP2003530384A
JP9502979A
JP2013543490A

Aoki Atsushi
Shinji Mihashi
Youichi Watanabe
Nakajima Masaru
Ryotaro Takei

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