Title:
プロリン及びモルホリン誘導体の新規化合物
Document Type and Number:
Japanese Patent JP2007536369
Kind Code:
A
Abstract:
The present invention relates to compounds with the formulas (I), (II), and (III), or a pharmaceutically acceptable salt thereof: wherein T is a (4 to 10)-membered heterocyclyl selected from the group consisting of and wherein R1, R2 and R3 are as defined in the specification. The invention also relates to pharmaceutical compositions comprising the compounds of formulas (I), (II), and (III) and methods of treating a condition that is mediated by the modulation of the 11-beta-hsd-1 enzyme, the method comprising administering to a mammal an effective amount of a compound of formulas (I), (II), and (III).
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Inventors:
Chen, Heng Miao
Smith, Christopher Ronald
One, Yong
Parrot, Timothy James
Dress, Claus Ruprecht
Nile, Sajib Krishnan
Hoffman, Jackie Elizabeth
Les von chi kui
Kuptin Skye, Stanley William
YANG,Yi
Clips, Stephen James
Fan, bwen
Smith, Christopher Ronald
One, Yong
Parrot, Timothy James
Dress, Claus Ruprecht
Nile, Sajib Krishnan
Hoffman, Jackie Elizabeth
Les von chi kui
Kuptin Skye, Stanley William
YANG,Yi
Clips, Stephen James
Fan, bwen
Application Number:
JP2007512545A
Publication Date:
December 13, 2007
Filing Date:
April 25, 2005
Export Citation:
Assignee:
Pfizer Inc.
International Classes:
C07D207/10; A61K31/165; A61K31/40; A61K31/401; A61K31/4025; A61K31/403; A61K31/4155; A61K31/4164; A61K31/4178; A61K31/426; A61K31/44; A61K31/4439; A61K31/445; A61K31/4545; A61K31/495; A61K31/497; A61K31/5375; A61K31/5377; A61P1/16; A61P3/04; A61P3/06; A61P3/10; A61P9/10; A61P19/10; A61P25/24; A61P25/28; A61P27/06; A61P29/00; A61P31/06; A61P31/12; C07C237/24; C07D207/16; C07D209/02; C07D211/26; C07D211/36; C07D211/60; C07D211/96; C07D233/42; C07D241/04; C07D241/24; C07D265/30; C07D277/06; C07D401/06; C07D401/12; C07D403/06; C07D405/06; C07D413/02; C07D413/06; C07D413/12; C07D417/06; C07D453/06; C07D471/04; A61P3/00
Attorney, Agent or Firm:
Yoshinobu Murofushi