Title:
新規化合物及びその薬理的に許容される塩
Document Type and Number:
Japanese Patent JP6815417
Kind Code:
B2
Abstract:
A compound represented by the general formula (1) below or a pharmacologically acceptable salt thereof :[In the formula (1),R1and R2may be the same or different and each represents a hydrogen atom, a halogen atom, a hydroxyl group, a carboxy group, a cyano group, an optionally substituted C1-6alkyl group et al.; R3represents a hydrogen atom; R4represents an optionally substituted 4- to 10-membered monocyclic heterocyclic group containing 1 to 4 heteroatoms selected from an oxygen atom, a nitrogen atom, and a sulfur atom; X represents a group represented by the following formula: -CH2-, - CH2-CH2-, -CH2-CH2-CH2-, or -CH2-O-CH2-; and Z represents a hydrogen atom or a hydroxyl group.]
Inventors:
Keiji Tamura
Ken Yamakawa
Satoshi Isshiki
Yoshiya Wakiyama
Shohei Ouchi
Takashi Matsudaira
Ishida Natsuki
Yuji Tabata
Ken Yamakawa
Satoshi Isshiki
Yoshiya Wakiyama
Shohei Ouchi
Takashi Matsudaira
Ishida Natsuki
Yuji Tabata
Application Number:
JP2018559513A
Publication Date:
January 20, 2021
Filing Date:
December 26, 2017
Export Citation:
Assignee:
meiji seika Pharma Co., Ltd.
International Classes:
C07D487/08; A61K31/4995; A61K31/5386; A61P1/00; A61P3/00; A61P11/00; A61P17/00; A61P35/00; A61P43/00; C07D471/08; C07D498/08
Domestic Patent References:
| JP2010500368A | ||||
| JP2003522771A | ||||
| JP2011500638A |
Foreign References:
| WO2015005429A1 |
Other References:
HEIDMANN, B. et al.,ChemMedChem,2016年 7月 8日,Vol. 11,pp. 2132-2146
CLARK, R. B. et al.,Discovery of Novel 2-((Pyridin-3-yloxy)methyl)piperazines as α7 Nicotinic Acetylcholine Receptor Mo,Journal of Medicinal Chemistry,2014年,Vol. 57,pp. 3966-3983,ISSN 0022-2623
CLARK, R. B. et al.,Discovery of Novel 2-((Pyridin-3-yloxy)methyl)piperazines as α7 Nicotinic Acetylcholine Receptor Mo,Journal of Medicinal Chemistry,2014年,Vol. 57,pp. 3966-3983,ISSN 0022-2623
Attorney, Agent or Firm:
Patent Business Corporation St. Crest International Patent Office