Title:
新規な化合物およびその使用
Document Type and Number:
Japanese Patent JP6450678
Kind Code:
B2
Abstract:
An anthraquinone compound of formula I (such as the compounds of formulae II to X) and processes for making the same are provided. Pharmaceutical compositions for use in the treatment of cancer, optionally in combination with an agent capable of reducing the level of oxygenation of a tumour, are also provided. Additionally, an option for combination with chemotherapeutic and radiotherapeutic modalities to enhance overall tumour cell kill is provided. Methods for the detection of cellular hypoxia, both in vivo and in vitro, are additionally provided.
Inventors:
Ogrozinski, Stephan
Smith, paul
McKeon, Stephanie
Lawrence Patterson
Rachel Jane, Ellington
Smith, paul
McKeon, Stephanie
Lawrence Patterson
Rachel Jane, Ellington
Application Number:
JP2015525943A
Publication Date:
January 09, 2019
Filing Date:
August 07, 2013
Export Citation:
Assignee:
Bio status limited
International Classes:
C07C225/36; A61K31/136; A61P1/02; A61P1/04; A61P1/16; A61P1/18; A61P5/28; A61P9/00; A61P11/00; A61P11/02; A61P11/04; A61P13/08; A61P13/10; A61P13/12; A61P15/00; A61P17/00; A61P19/00; A61P25/00; A61P27/02; A61P35/00; A61P35/02; A61P35/04; A61P43/00; C07C221/00; C07C291/04
Domestic Patent References:
| JP4502166A | ||||
| JP2006501140A |
Foreign References:
| US4197249 | ||||
| WO2006096458A2 | ||||
| WO2011124927A1 | ||||
| WO2006031719A2 | ||||
| US20090156807 |
Other References:
Analytical Chemistry,1988年,Vol.60, No.19,p.2090-2095
DATABASE REGISTRY (STN) RN 1189974-82-0, [online],2009年10月25日,[Retrieved on 2017.06.21]
DATABASE REGISTRY (STN) RN 1189974-82-0, [online],2009年10月25日,[Retrieved on 2017.06.21]
Attorney, Agent or Firm:
Ryoichi Takaoka
Nao Oda
Kaoru Takahashi
Nao Oda
Kaoru Takahashi