Title:
New conjugate containing TETRAGALNAC and the delivery method of an oligonucleotide
Document Type and Number:
Japanese Patent JP6239592
Kind Code:
B2
Abstract:
Disclosed herein is a modular composition comprising 1) an oligonucleotide; 2) one or more tetraGalNAc ligands of Formula (I), which may be the same or different; optionally, 3) one or more linkers, which may be the same or different; and optionally, 4) one or more targeting ligands, solubilizing agents, pharmacokinetics enhancing agents, lipids, and/or masking agents.
Inventors:
Tellers, david
Collecties, Stephen, Elle
Dadkin, badime
Ikemoto, Norihiro
Riao, Horn Biao
Parishushiyu, craig
Pay, Tao
Anthony
Troan, quan
One, Rigiyun
Yuan, You
Jiyu Man
Collecties, Stephen, Elle
Dadkin, badime
Ikemoto, Norihiro
Riao, Horn Biao
Parishushiyu, craig
Pay, Tao
Anthony
Troan, quan
One, Rigiyun
Yuan, You
Jiyu Man
Application Number:
JP2015510418A
Publication Date:
November 29, 2017
Filing Date:
May 01, 2013
Export Citation:
Assignee:
Sirna Therapeutics,Inc.
International Classes:
A61K31/7088; A61K31/7105; A61K31/713; A61K47/26; A61K47/54; A61K47/56; A61K48/00
Domestic Patent References:
| JP2011505425A |
Foreign References:
| WO2010039548A1 | ||||
| WO2011104169A1 |
Attorney, Agent or Firm:
Makoto Ono
Kenkyo Kanayama
Mitsuaki Tsubokura
Kazuki Shigemori
Kenji Ando
Yoshikazu Iwase
Yasufumi Shiroyama
Kenkyo Kanayama
Mitsuaki Tsubokura
Kazuki Shigemori
Kenji Ando
Yoshikazu Iwase
Yasufumi Shiroyama