Title:
新規な避妊薬とその調製方法
Document Type and Number:
Japanese Patent JP5484646
Kind Code:
B2
Abstract:
Female contraceptive compositions (A) comprise nomegestrol (or its ester) as progestational component (I) and estradiol (or its ester) as estrogenic component (II), associated or mixed with a diluent or vehicle, in a weight ratio of (I) to (II) at 0.5-5 (preferably 1-3). An independent claim is included for the production of (A), by combining (I) and (II) with one or more of diluents, filler, compression adjuvants, lubricants and/or disintegrating agents. ACTIVITY : Antifertility. Tests in 18-35 year old women having normal menstrual cycles involving administration of nomegestrol acetate (Ia) and estradiol (IIa) showed that (IIa) at 1.5 mg daily (i.e. a dose insufficient to block ovulation if used alone) potentiated the anti-ovulate effect of (Ia), so that an adequate ovulation inhibiting effect was obtained at low doses of (Ia) (i.we. 0.625 mg per day). MECHANISM OF ACTION : None given.
Inventors:
Paris, Jack
Thomas, Jean-Louis
Thomas, Jean-Louis
Application Number:
JP2001532776A
Publication Date:
May 07, 2014
Filing Date:
October 24, 2000
Export Citation:
Assignee:
LABORTOIR TERRAMEX
International Classes:
A61K9/14; A61K31/57; A61K9/20; A61K9/28; A61K9/48; A61K31/565; A61K31/575; A61P5/30; A61P15/18
Domestic Patent References:
| JP1129481A |
Foreign References:
| WO1998015279A1 | ||||
| WO1999013882A1 |
Attorney, Agent or Firm:
Takashi Koshiba