Title:
レボノルゲストレルの新規結晶混合物及びその製造方法
Document Type and Number:
Japanese Patent JP6433910
Kind Code:
B2
Abstract:
A levonorgestrel crystal mixture comprising polymorphic levonorgestrel crystals α which give an X-ray powder diffraction spectrum that has diffraction peaks at the following diffraction angles (α) in terms of 2θ and polymorphic levonorgestrel crystals β which give an X-ray powder diffraction spectrum that has diffraction peaks at the following diffraction angles (β) in terms of 2θ. The ratio (by weight) of the polymorphic crystals α to the polymorphic crystals β, former/latter, may be 5/95 to 90/10. (α): 17.2°±0.2°, 18.6°±0.2°, 22.7°±0.2°, 31.1°±0.2°, and 35.5°±0.2° (β): 13.9°±0.2°, 14.5°±0.2°, 21.3°±0.2°, 24.9°±0.2°, and 28.2°±0.2° This levonorgestrel crystal mixture is useful as emergency contraceptive pills, etc.
More Like This:
| WO/2009/033499 | TOTAL SYNTHESIS OF ENANTIOPURE DESOGESTREL |
Inventors:
Shigeki Iwashita
Hiroyuki Hayashi
Takayoshi Nakagawa
Koichi Miyazaki
Hiroyuki Hayashi
Takayoshi Nakagawa
Koichi Miyazaki
Application Number:
JP2015544961A
Publication Date:
December 05, 2018
Filing Date:
October 23, 2014
Export Citation:
Assignee:
Aska Pharmaceutical Co., Ltd.
International Classes:
C07J1/00; A61K31/567; A61P15/18
Foreign References:
| WO2009035527A1 | ||||
| WO2012110947A1 |
Other References:
QUINKERT,G. et al,Total synthesis with a chirogenic opening move demonstrated on steroids with estrane or 18a-homoestr,Helvetica Chimica Acta,1995年,Vol.78,p.1345-1391
CRABBE,P. et al,Long-acting contraceptive agents: X-ray study of levonorgestrel esters,Bulletin des Societes Chimiques Belges,1983年,Vol.92, No.3,p.275-287
DEANGELIS,N.J. et al,The crystal and molecular structure of d-norgestrel, a progestational steroid,Acta Crystallographica, Section B: Structural Crystallography and Crystal Chemistry,1975年,Vol.B31,p.2040-2043
川口洋子ら,医薬品と結晶多形,生活工学研究,2002年,Vol.4, No.2,p.310-317
CRABBE,P. et al,Long-acting contraceptive agents: X-ray study of levonorgestrel esters,Bulletin des Societes Chimiques Belges,1983年,Vol.92, No.3,p.275-287
DEANGELIS,N.J. et al,The crystal and molecular structure of d-norgestrel, a progestational steroid,Acta Crystallographica, Section B: Structural Crystallography and Crystal Chemistry,1975年,Vol.B31,p.2040-2043
川口洋子ら,医薬品と結晶多形,生活工学研究,2002年,Vol.4, No.2,p.310-317
Attorney, Agent or Firm:
Mitsuo Kata
Hiroshi Sanaka
Hiroshi Sanaka
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