Title:
免疫調節薬の新規な結晶形
Document Type and Number:
Japanese Patent JP2018515477
Kind Code:
A
Abstract:
本発明は、フォームB、フォームM、ポマリドミド:ゲンチジン酸の共結晶と命名されるポマリドミドの新規な固体結晶形およびその製造に関する。有利なことに、これらの固体形態は、多発性骨髄腫、炎症性疾患、自己免疫疾患、免疫疾患、骨髄異形成症候群、骨髄増殖性疾患、貧血、強皮症、アミロイドーシスまたは他の望ましくない血管新生に関連する疾患の治療および予防のための医薬組成物において使用される。
Inventors:
Alessandro Gagnani
Antonio Germani
Nicholas Tesson
Antonio Germani
Nicholas Tesson
Application Number:
JP2017556876A
Publication Date:
June 14, 2018
Filing Date:
November 24, 2016
Export Citation:
Assignee:
F.I.S. - Fabbrica Italiana Sintetici S.p.A.
International Classes:
C07D401/04; A61K31/454; A61P7/00; A61P7/06; A61P9/00; A61P17/00; A61P29/00; A61P35/00; A61P37/02; A61P37/06; A61P43/00; C07C65/05
Domestic Patent References:
JPH06298664A | 1994-10-25 | |||
JP2006518713A | 2006-08-17 |
Foreign References:
WO2014170909A2 | 2014-10-23 | |||
CN103626738A | 2014-03-12 | |||
WO2014160690A1 | 2014-10-02 | |||
WO2015036799A1 | 2015-03-19 | |||
WO2011050962A1 | 2011-05-05 | |||
WO2013012485A2 | 2013-01-24 | |||
WO2013126326A1 | 2013-08-29 |
Other References:
VISHWESHWAR, P. ET AL.: "Crystal engineering of pharmaceutical co-crystals from polymorphic active pharmaceutical ingredients", CHEMICAL COMMUNICATIONS, vol. (36), JPN7018003724, 2005, pages 4601 - 4603, XP002565290, ISSN: 0003912065, DOI: 10.1039/b501304f
LIAO, X. ET AL.: "Effect of Position Isomerism on the Formation and Physicochemical Properties of Pharmaceutical Co-Cr", JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 99(1), JPN6018043074, 2010, pages 246 - 254, ISSN: 0003912066
SONG, J. ET AL.: "Improving the Solubility of Lenalidomide via Cocrystals", CRYSTAL GROWTH & DESIGN, vol. 14(6), JPN6018043076, 2014, pages 3069 - 3077, ISSN: 0003912067
LIAO, X. ET AL.: "Effect of Position Isomerism on the Formation and Physicochemical Properties of Pharmaceutical Co-Cr", JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 99(1), JPN6018043074, 2010, pages 246 - 254, ISSN: 0003912066
SONG, J. ET AL.: "Improving the Solubility of Lenalidomide via Cocrystals", CRYSTAL GROWTH & DESIGN, vol. 14(6), JPN6018043076, 2014, pages 3069 - 3077, ISSN: 0003912067
Attorney, Agent or Firm:
Samejima Mutsumi
Yasushi Morimoto
Nobuhiko Akiyama
Yasushi Morimoto
Nobuhiko Akiyama