Title:
NEW CYANOIMIDAZOLE RIBONUCLEOSIDE DERIVATIVE AND ITS PREPARATION
Document Type and Number:
Japanese Patent JPS60193997
Kind Code:
A
Abstract:
NEW MATERIAL:A compound of formula I (R1, R2, R3 are H, protecting groups for hydroxyls) and its salt.
EXAMPLE: 4-Cyano-1-β-D-ribofuranosylimodazolium-5-oleate.
USE: A carcinostatic agent.
PREPARATION: The deprotection of a compound of formula II (R is protecting group for hydroxyl) such as 4-carbamoyl-1-(2,3,5-tri-O-acetyl)-β-D-ribofuranosyl)- imidazolium-5-oleate is carried out using phosphorus oxychloride, preferably by about 2mol amount to the compound for 2W3hr to give the compound of completely or partially deprotection.
Inventors:
TARUMI YUUZOU
ATAMI TOSHIO
FUKUI MASARU
ATAMI TOSHIO
FUKUI MASARU
Application Number:
JP4956384A
Publication Date:
October 02, 1985
Filing Date:
March 14, 1984
Export Citation:
Assignee:
SUMITOMO CHEMICAL CO
International Classes:
A61K31/70; A61K31/7042; A61K31/7052; A61K31/7056; A61P35/00; C07H19/052; (IPC1-7): A61K31/70; C07H19/052
Attorney, Agent or Firm:
Moroishi Mitsuhiro