Title:
新規なデプシペプチド化合物
Document Type and Number:
Japanese Patent JP3987909
Kind Code:
B2
Abstract:
The present invention relates to a novel compound which is useful as an agent for prevention and treatment of diseases associated with HDAC, in particular, tumor or cell proliferative diseases. The depsipeptide compound or its pharmaceutically acceptable salt of the present invention has a good HDAC inhibitory activity and an inhibitory activity of cell proliferation against human cancer cells and, therefore, is useful in treatment and improvement of diseases and pathogenic conditions associated with histone acetylation, in particular, tumor or cell proliferative diseases.
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Inventors:
Koji Nagai
Masami Taniguchi
Nobuaki Shindo
Hiroshi Terada
Masamichi Mori
Nobuaki Amino
Kenichi Suzumura
Yukio Takahashi
Mitsuo Amase
Masami Taniguchi
Nobuaki Shindo
Hiroshi Terada
Masamichi Mori
Nobuaki Amino
Kenichi Suzumura
Yukio Takahashi
Mitsuo Amase
Application Number:
JP2004532759A
Publication Date:
October 10, 2007
Filing Date:
August 28, 2003
Export Citation:
Assignee:
Astellas Pharma Inc.
International Classes:
C07K5/12; A61K38/00; A61P35/00; A61P43/00; C07K5/02; C07K5/027; C07K11/00
Domestic Patent References:
| JP2001348340A |
Foreign References:
| WO2000042062A1 |
Attorney, Agent or Firm:
Morita Taku
Emiko Yano
Emiko Yano