Title:
新規エピガロカテキンガレート4量体、およびそれらを含む血管内皮機能改善剤
Document Type and Number:
Japanese Patent JP5539881
Kind Code:
B2
Abstract:
Providing a compound capable of continuously taking and having a vascular endothelial function improving effect by enhancing NO function from the vascular endothelial cells. A compound represented by Formula (I) wherein R 1 , R 2 , R 3 and R 4 are each independently H or a gallate group, a vascular endothelial function improving agent, food and drink or pharmaceutical composition containing the compound.
Inventors:
Yuko Fukui
Mayu Imamoto
Mayu Imamoto
Application Number:
JP2010526791A
Publication Date:
July 02, 2014
Filing Date:
August 28, 2009
Export Citation:
Assignee:
Suntory Holdings Limited
International Classes:
C07D311/62; A23L1/30; A23L2/52; A61K31/353; A61P3/06; A61P3/10; A61P9/10; A61P9/12; A61P9/14
Domestic Patent References:
| JPH02187433A | 1990-07-23 | |||
| JPH10142726A | 1998-05-29 | |||
| JPH02187433A | 1990-07-23 | |||
| JPH10142726A | 1998-05-29 |
Foreign References:
| WO2005116005A1 | 2005-12-08 |
Other References:
JPN6009052057; ＫＵＢＡＲＡ， Ｂ． Ｋ．， ｅｔ ａｌ: 'Ｋｏｌａ ａｃｕｍｉｎａｔａ ｐｒｏａｎｔｈｏｃｙａｎｉｄｉｎｓ： ａ ｃｌａｓｓ ｏｆ ａｎｔｉ-ｔｒｙｐａｎｏｓｏｍａｌ ｃｏｍｐｏｕｎｄｓ ｅｆｆｅｃｔｉｖｅ ａｇａｉｎｓｔ Ｔｒｙｐａｎｏｓｏ' Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｊｏｕｒｎａｌ ｆｏｒ Ｐａｒａｓｉｔｏｌｏｇｙ ３５（１）, 2005, ９１-１０３
JPN6009052058; ＫＵＬＩＥＶ， Ｚ． Ａ．，ｅｔ．ａｌ: 'Ｏｌｉｇｏｍｅｒｉｃ ｐｒｏａｎｔｈｏｃｙａｎｉｄｉｎ ｇｌｙｃｏｓｉｄｅｓ ｏｆ Ｃｌｅｍｅｎｔｓｉａ ｓｅｍｅｎｏｖｉｉ ａｎｄ ｔｈｅｉｒ ｂｉｏｌｏｇｉｃａｌ ａｃｔｉｖｉｔｙ． ＩＩＩ' Ｃｈｅｍｉｓｔｒｙ ｏｆ Ｎａｔｕｒａｌ Ｃｏｍｐｏｕｎｄｓ （Ｔｒａｎｓｌａｔｉｏｎ ｏｆ Ｋｈｉｍｉｙａ Ｐｒｉｒｏｄｎｙｋｈ Ｓｏｅｄｉｎｅｎｉｉ） ３６（１）, 2000, ６０-６７
JPN6009052053; ＤＵＦＦＹ， Ｓ．Ｊ．， ｅｔ ａｌ: 'Ｓｈｏｒｔ-ａｎｄ Ｌｏｎｇ-Ｔｅｒｍ Ｂｌａｃｋ Ｔｅａ Ｃｏｎｓｕｍｐｔｉｏｎ Ｒｅｖｅｒｓｅｓ Ｅｎｄｏｔｈｅｌｉａｌ Ｄｙｓｆｕｎｃｔｉｏｎ ｉｎ Ｐａｔｉｅｎｔｓ Ｗｉｔｈ Ｃｏｒｏｎａｒｙ' Ｃｉｒｃｕｌａｔｉｏｎ １０４, 2001, １５１-１５６
JPN6009052057; ＫＵＢＡＲＡ， Ｂ． Ｋ．， ｅｔ ａｌ: 'Ｋｏｌａ ａｃｕｍｉｎａｔａ ｐｒｏａｎｔｈｏｃｙａｎｉｄｉｎｓ： ａ ｃｌａｓｓ ｏｆ ａｎｔｉ-ｔｒｙｐａｎｏｓｏｍａｌ ｃｏｍｐｏｕｎｄｓ ｅｆｆｅｃｔｉｖｅ ａｇａｉｎｓｔ Ｔｒｙｐａｎｏｓｏ' Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｊｏｕｒｎａｌ ｆｏｒ Ｐａｒａｓｉｔｏｌｏｇｙ ３５（１）, 2005, ９１-１０３
JPN6009052058; ＫＵＬＩＥＶ， Ｚ． Ａ．，ｅｔ．ａｌ: 'Ｏｌｉｇｏｍｅｒｉｃ ｐｒｏａｎｔｈｏｃｙａｎｉｄｉｎ ｇｌｙｃｏｓｉｄｅｓ ｏｆ Ｃｌｅｍｅｎｔｓｉａ ｓｅｍｅｎｏｖｉｉ ａｎｄ ｔｈｅｉｒ ｂｉｏｌｏｇｉｃａｌ ａｃｔｉｖｉｔｙ． ＩＩＩ' Ｃｈｅｍｉｓｔｒｙ ｏｆ Ｎａｔｕｒａｌ Ｃｏｍｐｏｕｎｄｓ （Ｔｒａｎｓｌａｔｉｏｎ ｏｆ Ｋｈｉｍｉｙａ Ｐｒｉｒｏｄｎｙｋｈ Ｓｏｅｄｉｎｅｎｉｉ） ３６（１）, 2000, ６０-６７
JPN6009052053; ＤＵＦＦＹ， Ｓ．Ｊ．， ｅｔ ａｌ: 'Ｓｈｏｒｔ-ａｎｄ Ｌｏｎｇ-Ｔｅｒｍ Ｂｌａｃｋ Ｔｅａ Ｃｏｎｓｕｍｐｔｉｏｎ Ｒｅｖｅｒｓｅｓ Ｅｎｄｏｔｈｅｌｉａｌ Ｄｙｓｆｕｎｃｔｉｏｎ ｉｎ Ｐａｔｉｅｎｔｓ Ｗｉｔｈ Ｃｏｒｏｎａｒｙ' Ｃｉｒｃｕｌａｔｉｏｎ １０４, 2001, １５１-１５６
JPN6009052058; ＫＵＬＩＥＶ， Ｚ． Ａ．，ｅｔ．ａｌ: 'Ｏｌｉｇｏｍｅｒｉｃ ｐｒｏａｎｔｈｏｃｙａｎｉｄｉｎ ｇｌｙｃｏｓｉｄｅｓ ｏｆ Ｃｌｅｍｅｎｔｓｉａ ｓｅｍｅｎｏｖｉｉ ａｎｄ ｔｈｅｉｒ ｂｉｏｌｏｇｉｃａｌ ａｃｔｉｖｉｔｙ． ＩＩＩ' Ｃｈｅｍｉｓｔｒｙ ｏｆ Ｎａｔｕｒａｌ Ｃｏｍｐｏｕｎｄｓ （Ｔｒａｎｓｌａｔｉｏｎ ｏｆ Ｋｈｉｍｉｙａ Ｐｒｉｒｏｄｎｙｋｈ Ｓｏｅｄｉｎｅｎｉｉ） ３６（１）, 2000, ６０-６７
JPN6009052053; ＤＵＦＦＹ， Ｓ．Ｊ．， ｅｔ ａｌ: 'Ｓｈｏｒｔ-ａｎｄ Ｌｏｎｇ-Ｔｅｒｍ Ｂｌａｃｋ Ｔｅａ Ｃｏｎｓｕｍｐｔｉｏｎ Ｒｅｖｅｒｓｅｓ Ｅｎｄｏｔｈｅｌｉａｌ Ｄｙｓｆｕｎｃｔｉｏｎ ｉｎ Ｐａｔｉｅｎｔｓ Ｗｉｔｈ Ｃｏｒｏｎａｒｙ' Ｃｉｒｃｕｌａｔｉｏｎ １０４, 2001, １５１-１５６
JPN6009052057; ＫＵＢＡＲＡ， Ｂ． Ｋ．， ｅｔ ａｌ: 'Ｋｏｌａ ａｃｕｍｉｎａｔａ ｐｒｏａｎｔｈｏｃｙａｎｉｄｉｎｓ： ａ ｃｌａｓｓ ｏｆ ａｎｔｉ-ｔｒｙｐａｎｏｓｏｍａｌ ｃｏｍｐｏｕｎｄｓ ｅｆｆｅｃｔｉｖｅ ａｇａｉｎｓｔ Ｔｒｙｐａｎｏｓｏ' Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｊｏｕｒｎａｌ ｆｏｒ Ｐａｒａｓｉｔｏｌｏｇｙ ３５（１）, 2005, ９１-１０３
JPN6009052058; ＫＵＬＩＥＶ， Ｚ． Ａ．，ｅｔ．ａｌ: 'Ｏｌｉｇｏｍｅｒｉｃ ｐｒｏａｎｔｈｏｃｙａｎｉｄｉｎ ｇｌｙｃｏｓｉｄｅｓ ｏｆ Ｃｌｅｍｅｎｔｓｉａ ｓｅｍｅｎｏｖｉｉ ａｎｄ ｔｈｅｉｒ ｂｉｏｌｏｇｉｃａｌ ａｃｔｉｖｉｔｙ． ＩＩＩ' Ｃｈｅｍｉｓｔｒｙ ｏｆ Ｎａｔｕｒａｌ Ｃｏｍｐｏｕｎｄｓ （Ｔｒａｎｓｌａｔｉｏｎ ｏｆ Ｋｈｉｍｉｙａ Ｐｒｉｒｏｄｎｙｋｈ Ｓｏｅｄｉｎｅｎｉｉ） ３６（１）, 2000, ６０-６７
JPN6009052053; ＤＵＦＦＹ， Ｓ．Ｊ．， ｅｔ ａｌ: 'Ｓｈｏｒｔ-ａｎｄ Ｌｏｎｇ-Ｔｅｒｍ Ｂｌａｃｋ Ｔｅａ Ｃｏｎｓｕｍｐｔｉｏｎ Ｒｅｖｅｒｓｅｓ Ｅｎｄｏｔｈｅｌｉａｌ Ｄｙｓｆｕｎｃｔｉｏｎ ｉｎ Ｐａｔｉｅｎｔｓ Ｗｉｔｈ Ｃｏｒｏｎａｒｙ' Ｃｉｒｃｕｌａｔｉｏｎ １０４, 2001, １５１-１５６
Attorney, Agent or Firm:
Shinjiro Ono
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Osamu Yamamoto
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Osamu Yamamoto