Title:
新規なヒトT細胞集団
Document Type and Number:
Japanese Patent JP5118624
Kind Code:
B2
Abstract:
The present invention has objects to provide a novel human T-cell population having both cytotoxic and immunosuppressive activities, and to a method for preparing the same. The above objects are attained by providing a human T-cell population which is obtainable by coculturing mononuclear cells, collected from human blood, with stroma cells and which has the following features:
(1) being positive for CD3, CD25, CD28 and T-cell antigen receptor ±²;
(2) essentially consisting of three groups of a CD4 positive and CD8 positive (CD4 + CD8 + ) T-cell group, a CD4 positive and CD8 dimly positive (CD4 + CD8 dim ) T-cell group, and a CD4 negative and CD8 positive (CD4 - CD8 + ) T-cell group;
(3) exerting a cytotoxic activity against the cocultured stroma cells; and
(4) exerting an immunosuppressive activity against activated T cells.
More Like This:
Inventors:
Shuji Nakamura
Ryuichi Motoda
Kiyoshi Masayoshi
Kaoru Orita
Mountain Saki History
Ryuichi Motoda
Kiyoshi Masayoshi
Kaoru Orita
Mountain Saki History
Application Number:
JP2008505206A
Publication Date:
January 16, 2013
Filing Date:
March 15, 2007
Export Citation:
Assignee:
Hayashibara Co., Ltd.
International Classes:
C12N5/0783; A61K35/14; A61K35/17; A61P35/00; A61P37/06; A61P37/08; C12N5/07; C12N5/071; C12N15/09
Other References:
JPN6012041728; ＮＡＫＡＭＵＲＡ，Ｓ． ｅｔ ａｌ．: 'ＩＬ-２-ｉｎｄｅｐｅｎｄｅｎｔ ｇｅｎｅｒａｔｉｏｎ ｏｆ ＦＯＸＰ３（＋）ＣＤ４（＋）ＣＤ８（＋）ＣＤ２５（＋） ｃｙｔｏｔｏｘｉｃ ｒｅｇｕｌａｔｏｒｙ Ｔ ｃｅｌｌ ｌｉｎｅｓ ｆｒｏｍ ｈｕ' Ｅｘｐ． Ｈｅｍａｔｏｌ． Ｖｏｌ．３５， Ｎｏ．２, 200702, ｐｐ．２８７-９６
JPN6012041728; ＮＡＫＡＭＵＲＡ，Ｓ． ｅｔ ａｌ．: 'ＩＬ-２-ｉｎｄｅｐｅｎｄｅｎｔ ｇｅｎｅｒａｔｉｏｎ ｏｆ ＦＯＸＰ３（＋）ＣＤ４（＋）ＣＤ８（＋）ＣＤ２５（＋） ｃｙｔｏｔｏｘｉｃ ｒｅｇｕｌａｔｏｒｙ Ｔ ｃｅｌｌ ｌｉｎｅｓ ｆｒｏｍ ｈｕ' Ｅｘｐ． Ｈｅｍａｔｏｌ． Ｖｏｌ．３５， Ｎｏ．２, 200702, ｐｐ．２８７-９６
JPN6012041728; ＮＡＫＡＭＵＲＡ，Ｓ． ｅｔ ａｌ．: 'ＩＬ-２-ｉｎｄｅｐｅｎｄｅｎｔ ｇｅｎｅｒａｔｉｏｎ ｏｆ ＦＯＸＰ３（＋）ＣＤ４（＋）ＣＤ８（＋）ＣＤ２５（＋） ｃｙｔｏｔｏｘｉｃ ｒｅｇｕｌａｔｏｒｙ Ｔ ｃｅｌｌ ｌｉｎｅｓ ｆｒｏｍ ｈｕ' Ｅｘｐ． Ｈｅｍａｔｏｌ． Ｖｏｌ．３５， Ｎｏ．２, 200702, ｐｐ．２８７-９６