To obtain a new compound comprising a hydroxamic acid derivative, capable of inhibiting metalloproteinases and excellent in physiological activities such as percutaneous absorbability or oral absorbability.
This compound is represented by formula I [R1 is H, a (substituted) aralkyl or the like; R2 is H, a (substituted) aralkyloxycarbonyl or the like; R3, R7 and R8 are each H, OH, a (substituted) alkyl or the like; R4 is a (substituted) alkyl or the like; R5 is H, a (substituted) alkyl or the like; R6 is H, OH or the like, X is O, a (substituted) 1-6C alkylene or the like; Y is A-B or the like; A is a (substituted) 1-6C alkylene or the like; B is H, amino or the like], e.g. Na-[4-(N-hydroxyamino)-2(R)-isobutyl-3(S)-(3-phenylpropyl) succinyl]-L-4'-aminomethylphenylalamine. The compound represented by formula I is obtained by respectively converting R9 and R11 to R13 of a compound represented by formula II into the objective groups R3 to R6 and then converting the CO2R10 site of the compound into an amide bond-containing site.
KOTAKE SHINJIRO
ITO HAJIME
YASUDA JUNKO
OTANI YOSHIKAZU
MORIKAWA TADANORI
| JPH09509662A | 1997-09-30 | |||
| JPH08505605A | 1996-06-18 | |||
| JPH05503719A | 1993-06-17 |
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