Title:
新規ヒドロキサム酸エステルおよびその医薬的使用
Document Type and Number:
Japanese Patent JP2007513098
Kind Code:
A
Abstract:
The invention relates to compounds of general formula I wherein D, E, F, G, W, Y, R1, A, R9, X, B, R8 are as defined herein, and pharmaceutically acceptable salts, hydrates, or solvates thereof, for use—alone or in combination with one or more other pharmaceutically active compounds—in therapy, for treating diseases associated with deregulated angiogenesis, such as cancer.
Inventors:
Jeff Fenceholt
Jacop Torhauge
Bjarne Neremark
Jacop Torhauge
Bjarne Neremark
Application Number:
JP2006541802A
Publication Date:
May 24, 2007
Filing Date:
December 02, 2004
Export Citation:
Assignee:
LEO Pharma A/S
International Classes:
C07C259/10; A61K31/166; A61K31/192; A61K31/235; A61K31/277; A61K31/343; A61K31/351; A61K31/37; A61K31/40; A61K31/415; A61K31/4164; A61K31/4166; A61K31/417; A61K31/4196; A61K31/42; A61K31/426; A61K31/427; A61K31/429; A61K31/44; A61K31/4402; A61K31/4406; A61K31/4409; A61K31/4412; A61K31/443; A61K31/4433; A61K31/4436; A61K31/4439; A61K31/444; A61K31/4545; A61K31/47; A61K31/4709; A61K31/4725; A61K31/495; A61K31/496; A61K31/505; A61K31/519; A61K31/5375; A61K31/5377; A61P1/16; A61P3/04; A61P5/14; A61P9/08; A61P9/10; A61P11/00; A61P11/06; A61P13/08; A61P13/10; A61P13/12; A61P15/00; A61P15/08; A61P17/00; A61P17/06; A61P19/00; A61P19/02; A61P25/28; A61P27/02; A61P27/06; A61P27/16; A61P29/00; A61P31/00; A61P35/00; A61P35/02; A61P35/04; A61P37/08; C07C229/56; C07C239/20; C07C255/58; C07C255/62; C07C271/16; C07C271/28; C07C311/04; C07C317/18; C07C323/18; C07D207/267; C07D211/22; C07D213/30; C07D213/36; C07D213/38; C07D213/53; C07D213/61; C07D213/64; C07D213/73; C07D213/74; C07D213/75; C07D213/76; C07D213/78; C07D213/79; C07D213/80; C07D213/81; C07D213/84; C07D215/12; C07D215/14; C07D231/12; C07D233/22; C07D233/61; C07D233/64; C07D233/76; C07D239/52; C07D239/54; C07D249/04; C07D249/12; C07D261/04; C07D261/08; C07D261/10; C07D265/26; C07D271/06; C07D277/20; C07D277/24; C07D277/28; C07D277/32; C07D277/46; C07D295/08; C07D295/16; C07D295/192; C07D307/12; C07D307/79; C07D309/04; C07D309/06; C07D311/14; C07D317/54; C07D317/62; C07D333/28; C07D401/12; C07D405/12; C07D407/12; C07D409/12; C07D413/06; C07D413/12; C07D417/12; C07D417/14; C07D487/04; C07D513/04
Domestic Patent References:
| JPH06263743A | 1994-09-20 | |||
| JP2001505873A | 2001-05-08 | |||
| JP2002524512A | 2002-08-06 | |||
| JP2000281659A | 2000-10-10 | |||
| JP2002322169A | 2002-11-08 | |||
| JP2003528070A | 2003-09-24 | |||
| JPH08208614A | 1996-08-13 | |||
| JPS438260B1 | ||||
| JPH09510471A | 1997-10-21 | |||
| JPH04261156A | 1992-09-17 | |||
| JPS49132100A | 1974-12-18 |
Foreign References:
| WO1997030047A1 | 1997-08-21 | |||
| WO2004085382A1 | 2004-10-07 | |||
| WO2003024222A1 | 2003-03-27 | |||
| WO2002055501A2 | 2002-07-18 | |||
| US20030176469A1 | 2003-09-18 | |||
| GB1343036A | 1974-01-10 |
Other References:
WOLF, ERHARD; KOHL, HANS: "Cyclization reactions of amino nitrogen substituted O-methyl o-aminobenzohydroxamates", JUSTUS LIEBIGS ANNALEN DER CHEMIE, vol. (7-8), JPN6010064439, 1975, DE, pages 1245 - 51, ISSN: 0001772267
KORBONITS, DEZSO; KANZEL-SZVOBODA, IDA; GONCZI, CSABA; SIMON, KALMAN; KOLONITS, PAL: "Ring transformation of 1,2-disubstituted 4(1H)-quinazolone oximes to 3,5-disubstituted 1,2,4-oxa", CHEMISCHE BERICHTE, vol. 122(6), JPN6010064441, 1989, DE, pages 1107 - 12, ISSN: 0001772269
KORBONITS, DEZSO; KOLONITS, PAL: "Recent results on the cyclization tendency of diacyl-2-aminobenzamidoximes", ACTA CHIMICA HUNGARICA, vol. 127(6), JPN6010064442, 1990, HU, pages 795 - 802, ISSN: 0001772270
KOHL, HANS; WOLF, ERHARD: "Cyclization reactions of O-alkyl o-(acylamino)benzohydroxamates", JUSTUS LIEBIGS ANNALEN DER CHEMIE, vol. 766, JPN6010064440, 1972, DE, pages 106 - 15, ISSN: 0001772268
KORBONITS, DEZSO; KANZEL-SZVOBODA, IDA; GONCZI, CSABA; SIMON, KALMAN; KOLONITS, PAL: "Ring transformation of 1,2-disubstituted 4(1H)-quinazolone oximes to 3,5-disubstituted 1,2,4-oxa", CHEMISCHE BERICHTE, vol. 122(6), JPN6010064441, 1989, DE, pages 1107 - 12, ISSN: 0001772269
KORBONITS, DEZSO; KOLONITS, PAL: "Recent results on the cyclization tendency of diacyl-2-aminobenzamidoximes", ACTA CHIMICA HUNGARICA, vol. 127(6), JPN6010064442, 1990, HU, pages 795 - 802, ISSN: 0001772270
KOHL, HANS; WOLF, ERHARD: "Cyclization reactions of O-alkyl o-(acylamino)benzohydroxamates", JUSTUS LIEBIGS ANNALEN DER CHEMIE, vol. 766, JPN6010064440, 1972, DE, pages 106 - 15, ISSN: 0001772268
Attorney, Agent or Firm:
Aoyama Aoi
Yasuo Shibata
Michiko Matsutani
Nagatoshi Shinagawa
Mina Shiga
Sakurai Yoko
Yasuo Shibata
Michiko Matsutani
Nagatoshi Shinagawa
Mina Shiga
Sakurai Yoko