Title:
新規な感染症治療薬
Document Type and Number:
Japanese Patent JP4024309
Kind Code:
B2
Abstract:
Novel compounds having three substituents in the cyclic partial structure thereof, such as a pyrrolidine or a benzene ring, for example, homophenylalanyl-trans-4-((S)-3-amino-2-hydroxypropionylamino)proline 5-indanylamide and N-(3-phenylpropyl)-3-((S)-2-hydroxy-3-aminopropionylamino)-5-(D-homophenylalanylamino)-benzamide. These compounds act on pathogenic microorganisms which have acquired tolerance to the existing antimicrobials and elevate the sensitivity to the antimicrobials, thus making them nontolerant. When used together with the antimicrobials, these compounds can efficaciously establish the prevention and/or treatment of microbial infectious diseases.
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Inventors:
Kiyoshi Nakayama
Masami Otsuka
Hiroaki Inagaki
Toshiyuki Nishi
Yohei Ishida
Masami Otsuka
Hiroaki Inagaki
Toshiyuki Nishi
Yohei Ishida
Application Number:
JP51922598A
Publication Date:
December 19, 2007
Filing Date:
October 22, 1997
Export Citation:
Assignee:
Daiichi Sankyo Co., Ltd.
International Classes:
C07C237/40; A61K31/167; A61K31/40; A61K31/4025; A61K31/428; A61K31/4709; A61K31/495; A61K31/55; A61K31/551; A61P31/04; C07C237/42; C07D207/14; C07D207/16; C07D241/04; C07D243/08; C07D255/02; C07D403/12; C07D405/06; C07D417/06
Other References:
Antimicrobial Agents and Chemotherapy, 1995年, Vol.39, No.9, p.1948-1953
Chemotherapy, 1995年, Vol.41, No.5, p.330-333
Biochimica et Biophysica Acta, 1992年, Vol.1110, No.2, p.144-150
Proceedings of the National Academy of Sciences of the Uuited States of America , 1991年, Vol.88, No.11, p.4781-4785
Antimicrobial Agents and Chemotherapy, 1993年, Vol.37, No.8, p.1624-1629
Chemotherapy, 1995年, Vol.41, No.5, p.330-333
Biochimica et Biophysica Acta, 1992年, Vol.1110, No.2, p.144-150
Proceedings of the National Academy of Sciences of the Uuited States of America , 1991年, Vol.88, No.11, p.4781-4785
Antimicrobial Agents and Chemotherapy, 1993年, Vol.37, No.8, p.1624-1629
Attorney, Agent or Firm:
Patent Service Corporation Patent Office Sykes