Title:
NEW INHIBITOR OF FABK AND FABI/K AND METHOD FOR PRODUCING THE SAME
Document Type and Number:
Japanese Patent JP2009091251
Kind Code:
A
Abstract:
To provide an inhibitor of FabK or FabI/K, because Streptococcus pneumoniae important in clinic has only FabK as an enoyl ACP reductase, and Pseudomonas aeruginosa and Enterococcus faecalis have both of the FabI and the FabK to require the inhibition of not only the FabI but also the FabK.
The inhibitor (I) of the FabK or the FabI/K is represented by formula (I) (wherein, Z is -NH-CO-NY-CH2-, formula (I'), -NA'-CO-CH2O-N=C(B')-, -O-CO-CH2O-N=C(B')- or -NA'-CO-).
Inventors:
KITAGAWA HIDEO
OZAWA TOMOHIRO
IIDA MAIKO
TAKAHATA SHO
YAMAMOTO YASUO
WATANABE HISASHI
OZAWA TOMOHIRO
IIDA MAIKO
TAKAHATA SHO
YAMAMOTO YASUO
WATANABE HISASHI
Application Number:
JP2006021372A
Publication Date:
April 30, 2009
Filing Date:
January 30, 2006
Export Citation:
Assignee:
MEIJI SEIKA KAISHA
International Classes:
C07C251/60; A61K31/167; A61K31/19; A61K31/22; A61K31/341; A61K31/4045; A61K31/4168; A61K31/417; A61K31/4178; A61K31/4184; A61K31/42; A61K31/421; A61K31/422; A61K31/426; A61K31/427; A61K31/428; A61K31/433; A61K31/437; A61K31/4402; A61K31/4409; A61K31/4439; A61K31/454; A61K31/495; A61K31/496; A61K31/497; A61K31/5377; A61K31/551; A61P1/00; A61P1/12; A61P9/00; A61P11/00; A61P11/02; A61P11/04; A61P13/02; A61P13/12; A61P15/00; A61P17/00; A61P17/02; A61P19/02; A61P19/08; A61P25/00; A61P27/02; A61P27/16; A61P29/00; A61P31/00; A61P31/02; A61P31/04; A61P31/10; A61P43/00; C07D209/14; C07D213/53; C07D213/75; C07D233/64; C07D233/88; C07D235/14; C07D241/18; C07D263/48; C07D277/20; C07D277/54; C07D277/82; C07D285/12; C07D285/135; C07D307/52; C07D401/04; C07D401/06; C07D401/10; C07D401/12; C07D403/12; C07D405/12; C07D409/12; C07D409/14; C07D413/12; C07D417/12; C07D417/14; C07D471/04; C07D513/04; C12N9/99