To obtain the subject new compound expressed by a specific formula, presenting excellent Na+/Ca2+ exchange mechanism inhibitory action, reperfusion arrhythmia-suppressive action and reductive action on myocardial infarction foci, thus useful for treating and preventing cardiac dysfunction, etc.
This new compound is expressed by formula I [R1-R3 are each H, a halogen, nitro, lower alkyl or lower alkoxyl; R4 and R5 are each H, a lower alkyl or substituted alkyl, or combined into (CH2)n; (z) is (CH2)m or CH2 O(CH2)2; (n) is 2 or 3; (m) is 1-3], pref. S-{2-[4-(4-nitrobenzyloxy) phenyl]ethyl}isourea. This compound of formula I is obtained, pref. e.g. by reaction between a compound of formula II (Y is a halogen, a alkylsulfonyloxy, etc.) and about an equivalent of a compound of formula II in an inert organic solvent such as methanol at room temperature to the boiling point of the solvent for 1-24h.
YAMAMOTO TAKESHI
OTAKA HIROSHI
NAKAJIMA FUMIO
HARADA KENGO
MORITA TOMINORI
