To obtain new macrolactins having excellent antimicrobial activity, and useful as an antimicrobial agent also effective to resistant bacteria, by culturing microorganisms belonging to the genus Bacillus and having ability to produce the macrolactins in a medium.
The new macrolactins include macrolactin-G, macrolactin-H, macrolactin-I, macrolactin-J, macrolactin-K and macrolactin-L expressed by formula I, formula II, formula III, formula IV, formula V and formula VI, respectively, having excellent antimicrobial activity, and being useful as an antimicrobial agent also effective to resistant bacteria. These new macrolactins are obtained by culturing microorganisms belonging to the genus Bacillus and having ability to produce the macrolactins G to L [e.g. Bacillus sp. PP19-H3 (FERM P-15407)] in a medium to produce an accumulate these compounds in the cultured product followed by collecting these compounds.
ADACHI KYOKO
ARAKI YOSHIO
NISHIJIMA MIYUKI
CHIN YOSHITAKA
SANO HIROSHI
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