To obtain a new compound useful as an optical resolution agent, and capable of providing a polymethacrylic acid ester having asymmetric structure in a side chain and a principal chain by polymerizing the compound.
This compound is the one of formula I (R1 and R2 are each a phenyl having 1-5 halogens; R3 is pyridyl), e.g. an optically active 2- fluorophenyl-4-fluorophenyl-2-pyridylmethyl methacrylate. The compound of formula I is manufactured, for example, by reacting 2-halogenopyridine (e.g. 2-bromopyridine) with a benzophenone derivative of formula II (e.g. 2,4'- difluorobenzophenone), reacting the product with a methacrylic acid halide (e.g. methacrylic acid chloride). The optically active compound of formula I is readily obtained from the asymmetric methacrylic acid ester obtained by the method, because the compound of formula I can be optically resolved by using a commercial column for optical resolution.
NAKANO TAMAKI
GO TAKESHI