Title:
新規方法
Document Type and Number:
Japanese Patent JP2010523523
Kind Code:
A
Abstract:
The invention related to a novel process, novel process steps and novel intermediates useful in the synthesis of pharmaceutically active compounds, especially renin inhibitors, such as Aliskiren, the invention relates to a process for the manufacture of a compound of the formula I, or a salt thereof, wherein R1 as well as Act are as defined in the specification, and processes of manufacturing this compound as well as intermediates in this process.
Inventors:
Gottfried Seedermeier
Application Number:
JP2010501501A
Publication Date:
July 15, 2010
Filing Date:
April 01, 2008
Export Citation:
Assignee:
Novartis Age
International Classes:
C07C201/12; C07C45/27; C07C47/198; C07C205/15; C07C205/29; C07C205/40; C07C205/44; C07C205/51; C07C269/00; C07C271/16; C07D201/08; C07D207/26; C07B53/00; C07B61/00
Domestic Patent References:
| JP2006028105A | 2006-02-02 | |||
| JP2004517805A | 2004-06-17 | |||
| JP2009514808A | 2009-04-09 | |||
| JP2009514808A | 2009-04-09 |
Foreign References:
| WO2005121137A1 | 2005-12-22 | |||
| WO2007013681A1 | 2007-02-01 | |||
| US4219660A | 1980-08-26 |
Other References:
JPN6011067461; Ｆｒａｎｚｅｎ， Ｊｏｈａｎ； Ｍａｒｉｇｏ， Ｍａｕｒｏ； Ｆｉｅｌｅｎｂａｃｈ， Ｄｏｒｉｓ； Ｗａｂｎｉｔｚ， Ｔｏｂｉａｓ Ｃ．； Ｋｊｒｓｇａａｒｄ， Ａｎｎｅ； Ｊｏｒｇｅｎｓｅｎ， Ｋａ: 'Ａ Ｇｅｎｅｒａｌ Ｏｒｇａｎｏｃａｔａｌｙｓｔ ｆｏｒ Ｄｉｒｅｃｔ alpha-Ｆｕｎｃｔｉｏｎａｌｉｚａｔｉｏｎ ｏｆ Ａｌｄｅｈｙｄｅｓ： Ｓｔｅｒｅｏｓｅｌｅｃｔｉｖｅ Ｃ-Ｃ， Ｃ-Ｎ， Ｃ-Ｆ' Ｊｏｕｒｎａｌ ｏｆ ｔｈｅ Ａｍｅｒｉｃａｎ Ｃｈｅｍｉｃａｌ Ｓｏｃｉｅｔｙ １２７（５１）, 2005, １８２
JPN5010006678; ＡＮＤＲＥＹ ＯＬＩＶＩＥＲ: ＡＤＶＡＮＣＥＤ ＳＹＮＴＨＥＳＩＳ ＆ ＣＡＴＡＬＹＳＩＳ Ｖ３４６, 20040209, Ｐ１１４７-１１６８
JPN5010006681; ＳＨＥＣＨＴＥＲ， ＨＡＲＯＬＤ: ＪＯＵＲＮＡＬ ＯＦ ＴＨＥ ＡＭＥＲＩＣＡＮ ＣＨＥＭＩＣＡＬ ＳＯＣＩＥＴＹ Ｖ７３, 1951, Ｐ３６６４-３６６５
JPN5012015638; ＤＯＮＧ Ｈ: 'ＰＲＡＣＴＩＣＡＬ ＳＹＮＴＨＥＳＩＳ ＯＦ ＡＮ ＯＲＡＬＬＹ ＡＣＴＩＶＥ ＲＥＮＩＮ ＩＮＨＩＢＩＴＯＲ ＡＬＩＳＫＩＲＥＮ' ＴＥＴＲＡＨＥＤＲＯＮ ＬＥＴＴＥＲＳ Ｖ４６ Ｎ３７, 20050912, Ｐ６３３７-６３４０, ＥＬＳＥＶＩＥＲ
JPN5008017132; ＤＯＮＧ ＨＵＡ: ＴＥＴＲＡＨＥＤＲＯＮ ＬＥＴＴＥＲＳ Ｖ４６ Ｎ３７, 20050728, Ｐ６３３７-６３４０
JPN5010006673; ＨＵＲＤ Ｃ Ｄ: ＪＯＵＲＮＡＬ ＯＦ ＴＨＥ ＡＭＥＲＩＣＡＮ ＣＨＥＭＩＣＡＬ ＳＯＣＩＥＴＹ Ｖ７４, 19521105, Ｐ５３２４-５３２９, ＡＭＥＲＩＣＡＮ ＣＨＥＭＩＣＡＬ ＳＯＣＩＥＴＹ
JPN6013013581; 'Ｕｎｓａｔｕｒａｔｅｄ ａｃｉｄｓ ａｎｄ ｍａｃｒｏｃｙｃｌｉｃ ｌａｃｔｏｎｅｓ' Ｉｚｖｅｓｔｉｙａ Ａｋａｄｅｍｉｉ Ｎａｕｋ ＳＳＳＲ， Ｓｅｒｉｙａ Ｋｈｉｍｉｃｈｅｓｋａｙａ Ｖｏｌ．８, 1964, ｐ．１４５３-１４５６
JPN6013013582; Ｓｙｎｌｅｔｔ Ｖｏｌ．８, 2000, ｐ．１１５１-１１５３
JPN5010006678; ＡＮＤＲＥＹ ＯＬＩＶＩＥＲ: ＡＤＶＡＮＣＥＤ ＳＹＮＴＨＥＳＩＳ ＆ ＣＡＴＡＬＹＳＩＳ Ｖ３４６, 20040209, Ｐ１１４７-１１６８
JPN5010006681; ＳＨＥＣＨＴＥＲ， ＨＡＲＯＬＤ: ＪＯＵＲＮＡＬ ＯＦ ＴＨＥ ＡＭＥＲＩＣＡＮ ＣＨＥＭＩＣＡＬ ＳＯＣＩＥＴＹ Ｖ７３, 1951, Ｐ３６６４-３６６５
JPN5012015638; ＤＯＮＧ Ｈ: 'ＰＲＡＣＴＩＣＡＬ ＳＹＮＴＨＥＳＩＳ ＯＦ ＡＮ ＯＲＡＬＬＹ ＡＣＴＩＶＥ ＲＥＮＩＮ ＩＮＨＩＢＩＴＯＲ ＡＬＩＳＫＩＲＥＮ' ＴＥＴＲＡＨＥＤＲＯＮ ＬＥＴＴＥＲＳ Ｖ４６ Ｎ３７, 20050912, Ｐ６３３７-６３４０, ＥＬＳＥＶＩＥＲ
JPN5008017132; ＤＯＮＧ ＨＵＡ: ＴＥＴＲＡＨＥＤＲＯＮ ＬＥＴＴＥＲＳ Ｖ４６ Ｎ３７, 20050728, Ｐ６３３７-６３４０
JPN5010006673; ＨＵＲＤ Ｃ Ｄ: ＪＯＵＲＮＡＬ ＯＦ ＴＨＥ ＡＭＥＲＩＣＡＮ ＣＨＥＭＩＣＡＬ ＳＯＣＩＥＴＹ Ｖ７４, 19521105, Ｐ５３２４-５３２９, ＡＭＥＲＩＣＡＮ ＣＨＥＭＩＣＡＬ ＳＯＣＩＥＴＹ
JPN6013013581; 'Ｕｎｓａｔｕｒａｔｅｄ ａｃｉｄｓ ａｎｄ ｍａｃｒｏｃｙｃｌｉｃ ｌａｃｔｏｎｅｓ' Ｉｚｖｅｓｔｉｙａ Ａｋａｄｅｍｉｉ Ｎａｕｋ ＳＳＳＲ， Ｓｅｒｉｙａ Ｋｈｉｍｉｃｈｅｓｋａｙａ Ｖｏｌ．８, 1964, ｐ．１４５３-１４５６
JPN6013013582; Ｓｙｎｌｅｔｔ Ｖｏｌ．８, 2000, ｐ．１１５１-１１５３
Attorney, Agent or Firm:
Mitsuo Tanaka
Takuji Yamada
Mitsutaka Iwasaki
Aoyama Aoi
Masayuki Nakagawa
Yasushi Ochiai
Takuji Yamada
Mitsutaka Iwasaki
Aoyama Aoi
Masayuki Nakagawa
Yasushi Ochiai