Title:
イレウスの治療及び予防のための新規な方法
Document Type and Number:
Japanese Patent JP5079961
Kind Code:
B2
Abstract:
Novel methods for the treatment and/or prevention of ileus. The methods may comprise administering to a patient an effective amount of a peripheral mu opioid antagonist compound. Preferred compounds for use in the methods include piperidine-N-alkylcarboxylates, quaternary morphinans, opium alkaloid derivatives and quaternary benzomorphans. The methods are particularly suitable for treating and/or preventing postsurgical ileus and postpartum ileus.
Inventors:
Farrer, John Jay
Squeeze, peter jay
Schmidt, William Kay
Carpenter, Randall El
Squeeze, peter jay
Schmidt, William Kay
Carpenter, Randall El
Application Number:
JP2001543508A
Publication Date:
November 21, 2012
Filing Date:
November 29, 2000
Export Citation:
Assignee:
Adler Corporation
International Classes:
A61K31/451; C07D221/26; A61K31/00; A61K31/439; A61K31/445; A61K31/473; A61K31/485; A61K45/00; A61P1/00; A61P43/00; C07D211/22; C07D489/00; C07D489/02
Other References:
MACK, D. J. et al ,Paralytic ileus: response to naloxone,BRITISH JOURNAL OF SURGERY ,1989年,vol.76, no.10,p.1101
ZIMMERMAN, D. M. et al,Discovery of a Potent, Peripherally Selective trans-3,4-Dimethyl-4-(3-hydroxyphenyl)piperidine Opioid Antagonist for the Treatment of Gastrointestinal Motility Disorders,J.MED.CHEM.,1994年,vol.37,p.2262-2265
ZIMMERMAN, D. M. et al,Discovery of a Potent, Peripherally Selective trans-3,4-Dimethyl-4-(3-hydroxyphenyl)piperidine Opioid Antagonist for the Treatment of Gastrointestinal Motility Disorders,J.MED.CHEM.,1994年,vol.37,p.2262-2265
Attorney, Agent or Firm:
Shinjiro Ono
Yasushi Kobayashi
Hiroyuki Tomita
Osamu Hoshino
Noriko Tsujimoto
Yasushi Kobayashi
Hiroyuki Tomita
Osamu Hoshino
Noriko Tsujimoto