Title:
NEW METHOTREXATE DERIVATIVE
Document Type and Number:
Japanese Patent JPH04352785
Kind Code:
A
Abstract:
PURPOSE: To provide the subject new compound having low toxicity and useful as an antirheumatic agent.
CONSTITUTION: The compound of formula I (R1 is 1-4C alkyl; R2 is H or together with R1 forms 2-3C methylene; R3 and R4 are H or 1-4C alkyl), e.g. N-[1-[(2,4-diamino-6-pteridinyl-)methyl]-indoline-5-carbonyl]-N-phthaloyl-ornithine methyl ester. The compound of formula I can be produced by condensing a compound of formula II with a compound of formula III, deprotecting the product, condensing the resultant compound of formula IV with a compound of formula V, deprotecting the product and reacting with a compound of formula VI.
Inventors:
MATSUOKA KOJI
KATO NOBUAKI
TSUJI KEIICHIRO
KATO NOBUAKI
TSUJI KEIICHIRO
Application Number:
JP22815891A
Publication Date:
December 07, 1992
Filing Date:
May 30, 1991
Export Citation:
Assignee:
CHUGAI PHARMACEUTICAL CO LTD
International Classes:
A61K31/505; A61K31/519; A61P29/00; C07D475/08; (IPC1-7): A61K31/505; C07D475/08