To obtain the subject compound enabling the protection of mitochondria exposed to the stress of anoxia and the recovery of ATP synthesis of an oxygen-deficient organ and capable of passing through the blood-brain barrier.
This compound is expressed by formula I (R1 is a straight or branched chain 1-6C alkyl; X is O or S; R2 is straight or branched chain 1-8C alkyl, a straight or branched chain 1-6C alkoxy, phenyl, a 3-7C cycloalkyl, etc.; R3 is H, a 3-7C cycloalkyl, formyl, phenyl, etc.), its isomer or an addition salt with a pharmaceutically permissible acid or base, e.g. N-(3,4-dimethoxy-2-E- phenylcyclopropylcarbonyloxy)benzyl-N'-ethylpiperazine dihydrochloride. The compound of formula I can be produced e.g. by reacting the starting substance of formula II with a substituted piperazine of formula III the presence of formaldehyde and then reacting with a carboxylic acid, etc., of the formula R2CO2H.
BOUSSARD MARIE FRANCOISE
LABIDALLE SERGE
GUYOT DANIEL
ROLLAND YVES
TILLEMENT JEAN PAUL
TESTA BERNARD
CREVAT AIME
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