Title:
NEW NAPHTHALENE COMPOUND, ITS PRODUCTION, AND MEDICINE COMPOSITION CONTAINING THE SAME COMPOUND
Document Type and Number:
Japanese Patent JP3776608
Kind Code:
B2
Abstract:
PROBLEM TO BE SOLVED: To obtain a new compound useful for, e.g. treatment of seasonal emotional disturbance, dysgryphia, cardiovascular disease, asomnia and fatigue resulting from jet lag, anorexia, and adiposis.
SOLUTION: This compound is shown by formula I [A and B rings, when combined with each other, forms (1,2-dihydro)naphthalene, tetrahydronaphthalene or the like; T is a 1-6C alkylene chain which may be substituted by a 1-6C alkyl, OH or the like; R is H, OH or the like; G1 is COOH, formyl, cyano or the like; and G2 is shown by formula II (X is O or S; R2 is H or a 1-6C alkyl; R21 is a (substituted) 1-6C alkyl, (substituted) heteroaryl or the like) or the like] (enantiomer, diastereoisomer or addition salt) e.g. N-[2-(7-methoxy-3- phenyl-1-naphthyl)ethyl]acetamide. The compound shown by formula I can be obtained by, e.g. reacting a compound shown by formula III (G3 is COOH or NH-R2) with a compound shown by formula IV to produce a compound shown by formula V, and reacting the product compound with a sulfiding reagent.
Inventors:
Francois Lefron
Luk Dumunk
Daniel Lesur
Patrick Dupry
Caroline Benjan
Pierre Renard
Philippe De Lagrange
Luk Dumunk
Daniel Lesur
Patrick Dupry
Caroline Benjan
Pierre Renard
Philippe De Lagrange
Application Number:
JP33866998A
Publication Date:
May 17, 2006
Filing Date:
November 30, 1998
Export Citation:
Assignee:
Réra Bora Toir Servier
International Classes:
C07C233/17; A61K31/00; A61K31/10; A61K31/16; A61K31/165; A61K31/17; A61K31/18; A61K31/34; A61K31/341; A61K31/38; A61K31/381; A61K31/44; A61K31/4402; A61K31/4406; A61P25/20; A61P43/00; C07C233/05; C07C233/18; C07C233/22; C07C233/31; C07C233/36; C07C233/47; C07C233/58; C07C233/60; C07C255/66; C07C275/24; C07C309/65; C07C317/14; C07C317/22; C07C317/32; C07C327/42; C07C335/06; C07D213/56; C07D233/60; C07D307/12; C07D307/52; C07D307/54; C07D333/16; C07D333/20; (IPC1-7): C07C233/17; A61K31/00; A61K31/00; A61K31/10; A61K31/165; A61K31/17; A61K31/18; A61K31/34; A61K31/38; A61K31/44; C07C275/24; C07C309/65; C07C317/14; C07C317/22; C07C317/32; C07C327/42; C07C335/06; C07D213/56; C07D307/54; C07D333/20
Domestic Patent References:
| JP7224017A | ||||
| JP8325217A | ||||
| JP9003016A | ||||
| JP8337564A | ||||
| JP10505596A | ||||
| JP10502336A |
Foreign References:
| US3467710 | ||||
| US5468898 |
Other References:
ERNEST,I. et al.,HELVETICA CHIMICA ACTA,1993年,Vol.76,p.1539-1563
Attorney, Agent or Firm:
Hajime Tsukuni
Mutsuo Watanabe
Fumio Shinoda
Tomoko Saeki
Mutsuo Watanabe
Fumio Shinoda
Tomoko Saeki