To obtain the subject compound free from toxicity, having extremely high selective affinity for melanin receptor, exhibiting substantial activity on central nervous system and useful for treatment of sleep disorder by reacting the required compounds.
This compound is represented by formula I [X is O or S; R1 is H, a (cyclo)alkyl, a cycloalkylalkyl or an aryl(alkyl); R2 is H, an (un) substituted alkyl, an (un)substituted alkenyl, an (un)substituted alkynyl, an (un) substituted cycloalkyl(alkyl) or the like; Ar is an (un)substituted naphthyl, indolyl, benzofuranyl, benzothiophenyl or the like], preferably O-[(7- methoxynapha-1-yl)methyl]-N-acetylhydroxylamine. The compound is obtained by reacting a compound of formula II with a compound of formula III (Hal is a halogen) or the corresponding acid anhydride or formic acid.
MITSUSHIERU RANGUROWA
PIEERU RENAARU
FUIRITSUPU DOURAGURANJIYU
