Title:
NEW OPTICALLY ACTIVE FLUORINE-CONTAINING COMPOUND, METHOD FOR PRODUCING THE SAME, AND METHOD FOR PRODUCING OPTICALLY ACTIVE 3,3,3-TRIFLUOROALANINE USING THE SAME
Document Type and Number:
Japanese Patent JP2012176902
Kind Code:
A
Abstract:
To provide a highly selective and efficient method for producing an optically active 3,3,3-trifluoroalanine and an optical active 2-methylpropyl-2-sulfinic acid (1-cyano-2,2,2-trifluoroethyl)amide as an intermediate of the above compound, which are useful as pharmaceutical or agrichemical intermediates.
Optically active 3,3,3-trifluoroalanine is obtained by reacting optical active trifluoromethyl tert-butylsulfinimide with a cyaniding agent to produce optically active 2-methylpropyl-2-sulfinic acid (1-cyano-2,2,2-trifluoroethyl)amide, and then hydrolyzing the product.
Inventors:
SHIGEHIRO HIROKI
KAGAWA TAKUMI
KAGAWA TAKUMI
Application Number:
JP2011039479A
Publication Date:
September 13, 2012
Filing Date:
February 25, 2011
Export Citation:
Assignee:
TOSOH F TECH INC
International Classes:
C07C313/06; B01J31/02; B01J31/22; C07C227/18; C07C229/20; C07B53/00; C07B61/00
Domestic Patent References:
| JP4173909B1 | 2008-10-29 |
Other References:
JPN6014052607; Ｍａｒｃｅｌｌｏ Ｃｒｕｃｉａｎｅｌｌｉ: 'Ｆａｃｉｌｅ ａｎｄ Ｓｔｅｒｅｏｓｅｌｅｃｔｉｖｅ Ｓｙｎｔｈｅｓｉｓ ｏｆ Ｎｏｎ-Ｒａｃｅｍｉｃ ３，３，３-Ｔｒｉｆｌｕｏｒｏａｌａｎｉｎｅ' ＭＯＬＥＣＵＬＥＳ ５（１２）, 2000, １２５１-１２５８
JPN6014052608; Ａｙｈａｎ Ｓ． Ｄｅｍｉｒ: 'Ａｎ ａｓｙｍｍｅｔｒｉｃ ｓｙｎｔｈｅｓｉｓ ｏｆ ｂｏｔｈ ｅｎａｎｔｉｏｍｅｒｓ ｏｆ ２，２，２-ｔｒｉｆｌｕｏｒｏ-１-ｆｕｒａｎ-２-ｙｌ-ｅｔｈｙｌａｍｉｎｅ ａｎｄ ３，３，３-ｔｒｉ' ＴＥＴＲＡＨＥＤＲＯＮ： ＡＳＹＭＭＥＴＲＹ １２（１６）, 2001, ２３０９-２３１３
JPN6014052609; Ｈｕａ Ｗａｎｇ: 'Ｓｏｌｖｅｎｔ-Ｃｏｎｔｒｏｌｌｅｄ Ａｓｙｍｍｅｔｒｉｃ Ｓｔｒｅｃｋｅｒ Ｒｅａｃｔｉｏｎ： Ｓｔｅｒｅｏｓｅｌｅｃｔｉｖｅ Ｓｙｎｔｈｅｓｉｓ ｏｆ alpha-Ｔｒｉｆｌｕｏｒｏｍｅｔｈｙｌａｔｅｄ' ＯＲＧＡＮＩＣ ＬＥＴＴＥＲＳ ８（７）, 2006, １３７９-１３８１
JPN6014052608; Ａｙｈａｎ Ｓ． Ｄｅｍｉｒ: 'Ａｎ ａｓｙｍｍｅｔｒｉｃ ｓｙｎｔｈｅｓｉｓ ｏｆ ｂｏｔｈ ｅｎａｎｔｉｏｍｅｒｓ ｏｆ ２，２，２-ｔｒｉｆｌｕｏｒｏ-１-ｆｕｒａｎ-２-ｙｌ-ｅｔｈｙｌａｍｉｎｅ ａｎｄ ３，３，３-ｔｒｉ' ＴＥＴＲＡＨＥＤＲＯＮ： ＡＳＹＭＭＥＴＲＹ １２（１６）, 2001, ２３０９-２３１３
JPN6014052609; Ｈｕａ Ｗａｎｇ: 'Ｓｏｌｖｅｎｔ-Ｃｏｎｔｒｏｌｌｅｄ Ａｓｙｍｍｅｔｒｉｃ Ｓｔｒｅｃｋｅｒ Ｒｅａｃｔｉｏｎ： Ｓｔｅｒｅｏｓｅｌｅｃｔｉｖｅ Ｓｙｎｔｈｅｓｉｓ ｏｆ alpha-Ｔｒｉｆｌｕｏｒｏｍｅｔｈｙｌａｔｅｄ' ＯＲＧＡＮＩＣ ＬＥＴＴＥＲＳ ８（７）, 2006, １３７９-１３８１
Attorney, Agent or Firm:
Mizuno Katsufumi
Masayuki Kishida
Hiroshin Takano
Masayuki Kishida
Hiroshin Takano
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