Title:
新規フェノール誘導体およびそれらを有効成分とする抗トリパノソーマ予防・治療剤
Document Type and Number:
Japanese Patent JP4662851
Kind Code:
B2
Abstract:
A compound represented by formula (I):
[wherein, for example, X is a hydrogen atom or a halogen atom; R 1 is a hydrogen atom; R 2 is a hydrogen atom or a C 1-4 alkyl group; R 3 is -CHO or -COOH; and R 4 is -CH=CH-(CH 2 ) p -CH 3 (wherein p is an integer of 1 to 12), -CH(OH)-(CH 2 ) q -CH 3 (wherein q is an integer of 1 to 13),
-CH(OH)-CH 2 -CH(CH 3 )-(CH 2 ) 2 -CH=C(CH 3 ) 2 , -CH=CH-CH(CH 3 )-(CH 2 ) 3- CH(CH 3 ) 2 , -(CH 2 ) 2 -CH(CH 3 )-(CH 2 ) 3 -CH(CH 3 ) 2 or -(CH 2 ) 8 -CH 3 ], an optical isomer thereof and a pharmaceutically acceptable salt thereof. These compounds have antitrypanosoma activity, and accordingly are useful as drugs for preventing or treating the diseases caused by trypanosoma.
Inventors:
Hiroyuki Saimoto
Yoshihiro Shigemasa
Kiyoshi Kita
Yasudabu Yabu
Tomoyoshi Hosokawa
Masakazu Yamamoto
Yoshihiro Shigemasa
Kiyoshi Kita
Yasudabu Yabu
Tomoyoshi Hosokawa
Masakazu Yamamoto
Application Number:
JP2005514824A
Publication Date:
March 30, 2011
Filing Date:
October 18, 2004
Export Citation:
Assignee:
Alligen Pharmaceutical Co., Ltd.
International Classes:
C07C47/56; A61K31/11; A61K31/235; A61K31/341; A61K47/10; A61P33/02; C07C47/565; C07C47/575; C07C65/01; C07C69/84; C07D307/32
Domestic Patent References:
| JPH06206843A | 1994-07-26 | |||
| JPH06245778A | 1994-09-06 | |||
| JPH09165332A | 1997-06-24 |
Attorney, Agent or Firm:
Kazuo Shamoto
Tadashi Masui
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Tadashi Masui
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita