Title:
新規なフェニルピペラジン
Document Type and Number:
Japanese Patent JP4919565
Kind Code:
B2
Abstract:
The invention relates to a novel group of phenylpiperazines having interesting pharmacological properties such as a high affinity for the dopamine D2 receptor and/or the serotonin reuptake site, and the ability to treat conditions related to disturbances in the dopaminergic and/or the serotonergic systems such as anxiety disorders, depression, Parkinson's disease, and schizophrenia. The invention relates to a group of novel phenylpiperazine derivatives of the formula (I): wherein: X is a group of formula 1, 2, 3, 4, 5, 6, or 7 as defined in the text, m has the value 2 to 6; n has the value 0-2; R5 and R6 are independently H or alkyl (1-3C); or R5+R6 represent a group -(CH2)-p wherein p has the value 3-5, and R7 is alkyl (1-3C), alkoxy (1-3C), halogen or cyano; or R6+R7 (R7 at position 7 of the indole group) represent a group -(CH2)q wherein q has the value 2-4, and salts thereof.
Inventors:
Ban Hess, Rolov
Van der Haden, Johannes A.M.
Kruze, Cornelis G
Tape car, jacobs
Toulup, Marteinus T.M.
Bisser, Guerben M
Van Burrito, Bernard Theei
Van der Haden, Johannes A.M.
Kruze, Cornelis G
Tape car, jacobs
Toulup, Marteinus T.M.
Bisser, Guerben M
Van Burrito, Bernard Theei
Application Number:
JP2001518420A
Publication Date:
April 18, 2012
Filing Date:
August 22, 2000
Export Citation:
Assignee:
Abbott Healthcare Products B.V.
International Classes:
C07D209/34; A61K31/404; C07D401/14; A61K31/4184; A61K31/428; A61K31/4709; A61K31/496; A61K31/497; A61K31/538; A61K31/541; A61K31/5415; A61K31/55; A61P1/08; A61P25/00; A61P25/16; A61P25/18; A61P25/22; A61P25/24; C07D209/00; C07D209/40; C07D401/12; C07D403/12; C07D403/14; C07D405/12; C07D405/14; C07D413/12; C07D413/14; C07D417/12; C07D417/14; C07D471/04; C07D471/06; A61P43/00; C07D
Domestic Patent References:
| JPH02225460A | 1990-09-07 | |||
| JPH07149762A | 1995-06-13 | |||
| JP2002535322A | 2002-10-22 | |||
| JP2003521443A | 2003-07-15 |
Foreign References:
| WO1999003855A1 | 1999-01-28 |
Attorney, Agent or Firm:
Patent business corporation Odashima patent office