Title:
NEW PHYSIOLOGICALLY ACTIVE SUBSTANCE NA00226B AND C, ITS PRODUCTION AND USE
Document Type and Number:
Japanese Patent JPH1160589
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To obtain the new subject substance useful as an antiasthmatic agent, a bronchodilator, a therapeutic agent for bronchitis, obtainable from a strain belonging to the genus Streptomyces, having inhibitory actions on phosphodiesterase. SOLUTION: This new substance is a physiologically active substance NA00226B showing the following physical and chemical properties or its pharmaceutically acceptable salt. Appearance: red powder. Molecular weight: 447. Molecular formula: C23 H29 NO8 . Solubility: soluble in a lower alcohol and insoluble in hexane, petroleum ether and water. Rf value by ODS thin film chromatography: 0.42 by a developing solvent of acetonitrile-water-formic acid (50:50:1 v/v). Color reaction: positive in vanillin-sulfuric acid, iron chloride and iodine, etc. The physiologically active substance is obtained by culturing a bacterium belonging to the genus Streptomyces capable of producing a physiologically active NA00226B in a medium, forming and accumulating the substance in the culture product and collecting the substance.
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Inventors:
NISHIGORI TAKAAKI
TSUCHIYA KOICHI
KOBAYASHI SHINICHI
NISHIDE MITSUYUKI
ISHIDA KOICHI
TSUCHIYA KOICHI
KOBAYASHI SHINICHI
NISHIDE MITSUYUKI
ISHIDA KOICHI
Application Number:
JP24026197A
Publication Date:
March 02, 1999
Filing Date:
August 22, 1997
Export Citation:
Assignee:
NIPPON KAYAKU KK
International Classes:
C12P1/06; A61K45/00; A61P7/02; A61P9/00; A61P9/06; A61P11/00; A61P25/24; A61P25/26; A61P29/00; A61P35/02; A61P37/08; C07G99/00; C12N1/20; C12R1/465; (IPC1-7): C07G17/00; A61K45/00; C12N1/20; C12P1/06