To produce the subject new physiologically active substance capable of exhibiting inhibiting actions on cell proliferation and useful as a chemotherapeutic agent, etc. for malignant tumors by culturing a microorganism belonging to the genus Streptomyces and having the ability to produce the physiologically active substance NK34944.
This new physiologically active substance NK34944 (salt) is represented by the formula and is capable of exhibiting inhibiting actions on cell proliferation and expected as an anticancer substance used as a chemotherapeutic agent, etc. for malignant tumors. The new physiologically active substance is produced by culturing a microorganism belonging to the genus Streptomyces and having the ability to produce the physiologically active substance NK34944 [e.g. Streptomyces sp. NA34944 (FERM P-17442) strain] in a nutrient culture medium, producing and accumulating the physiologically active substance NK34944 in the cultured product and then collecting the resultant physiologically active substance NK34944.
YAMAZAKI TADAO
AOYAMA TAKAYUKI
HARADA TAKASHI
MASUDA KUNIKO
SUKENAGA YOSHIKAZU
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