Title:
新規なポリペプチドおよびその製造方法
Document Type and Number:
Japanese Patent JP5070442
Kind Code:
B2
Abstract:
A process for producing a novel polypeptide, which comprises
reacting a peptide component (A) represented by the following formula (1a) with a peptide componant (B) represented by the following formula (2a) and a compound (C) represented by the following formula (3a), as an optional component:
X-(Pro-Y-Gly) n -OH(1a)
wherein "X" represents H or the group HOOC-(CH 2 ) m -CO-, ("m" denotes an integer of 1 to 18), "Y" represents Pro or Hyp, and "n" denotes an integer of 1 to 20,
X-(Z) r -OH(2a)
wherein "X" represents H or the group HOOC-(CH 2 ) m -CO-("m" denotes an integer of 1 to 18), "Z" represents a peptide chain comprising 1 to 10 amino acid residue(s), and "r" denotes an integer of 1 to 20,
H 2 N-R-NH 2 (3a)
wherein "R" represents a linear or branched alkylene group,
wherein the ratio of the peptide component (A) relative to the peptide component (B) [the former (A)/the latter (B)] is 100/0 to 30/70 (mol%); provided that
in the case where "X" represents the group HOOC-(CH 2 ) m -CO-("m" has the same meaning as defined above) in the formula (1a) and/or (2a), the amount of the compound (C) is substantially 1 mol relative to 1 mol of the total molar amount of the peptide component (A) and/or the peptide component (B); and
in the case where "X" represents H in the formula (1a) and/or (2a), the reaction is conducted without the compound (C). The present invention provides a collagenous polypeptide which is free from a risk of an infection by a pathogenic organism (or a causative factor) or anundesirable side effect, and which has a high safety.
Inventors:
Masao Tanihara
Otsuki main tax
Hiroshi Mikami
Hisao Kinoshita
Otsuki main tax
Hiroshi Mikami
Hisao Kinoshita
Application Number:
JP2003042518A
Publication Date:
November 14, 2012
Filing Date:
February 20, 2003
Export Citation:
Assignee:
Phg inc.
International Classes:
A61L27/00; C07K14/00; A23L1/305; A61K8/65; A61K38/17; A61L15/00; C07K1/02; C07K1/04; C07K1/06; C07K1/10; C07K7/08; C07K14/435; C07K14/78; C07K17/14; C07K19/00
Other References:
特表2001-514189号公報
J.Mol.Biol.,1972,Vol.63,p.85-99
BIOPOLYMERS,1976,Vol.15,p.2005-2024
Int.J.Peptide Protein Res.,1995,Vol.46,p.453-463
J.Mol.Biol.,1972,Vol.63,p.85-99
BIOPOLYMERS,1976,Vol.15,p.2005-2024
Int.J.Peptide Protein Res.,1995,Vol.46,p.453-463
Attorney, Agent or Firm:
Mitsuo Kata