NEW PYRIMIDINEDIONE DERIVATIVE

Japanese Patent JPH06128238

A

PURPOSE: To provide a new pyrimidinedione derivative having potassium channel opening activity and applicable for the treatment and prevention of disorders caused by the constriction of vascular smooth muscle and other smooth muscle.

CONSTITUTION: The compound of formula I [R1 and R2 are H, 1-6C alkyl or 1-6C alkenyl; R3 and R4 are 1-4C alkyl or together form 2-5C polymethylene; W is H or OH; A is group of formula II (Y1 and Y2 are H, alkylcarbonyl, NH2, NO2, CN, Cl, CF3, alkylsulfonyl, alkoxysulfinyl, alkoxy, cyanomethyl, etc.), 3-pyridyl or 4-pyridyl; X is 1-6C alkyl or NO2], e.g. 6-[4-[3(4- acetylphenoxy)-2-hydroxy-3-methylbutyl]piperazin-1-yl]-1,3-diisopropyl-2,4(1H,3H) pyrimidinedione. The compound of formula I wherein W is OH can be produced by reacting a uracilpiperazine derivative of formula III with a propane oxide derivative of formula IV.

KAIHO TATSUO
YOKOYAMA TATSURO
MORI HARUKI
FUJIWARA JUNYA
NOBORI TADAHITO
ODAKA HIDEO
KAMIYA JOJI
MARUYAMA MASAHIKO
SUGAWARA TATSURO

JP28164192A

May 10, 1994

October 20, 1992

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MITSUI TOATSU CHEMICALS

A61K31/505; A61P9/00; A61P9/08; A61P9/10; A61P9/12; A61P11/00; A61P13/02; A61P15/00; A61P17/00; A61P43/00; C07C43/215; C07C43/225; C07C43/235; C07C69/62; C07C69/96; C07C205/37; C07C255/54; C07C271/28; C07C275/34; C07C279/28; C07C309/63; C07C309/72; C07C311/08; C07C335/40; C07D213/64; C07D213/65; C07D239/54; C07D301/12; C07D301/14; C07D301/19; C07D303/16; C07D401/12; C07D405/12; (IPC1-7): C07D239/54; A61K31/505; C07C43/215; C07C43/225; C07C43/235; C07C69/62; C07C69/96; C07C205/37; C07C255/54; C07C271/28; C07C275/34; C07C279/28; C07C309/63; C07C309/72; C07C311/08; C07C335/40; C07D213/64; C07D213/65; C07D301/12; C07D301/14; C07D301/19; C07D303/16; C07D401/12; C07D405/12

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