Title:
新規な4級アンモニウム化合物
Document Type and Number:
Japanese Patent JP4497472
Kind Code:
B2
Abstract:
Drugs useful for the treatment and prevention of hyperlipidemia, moreover drugs useful for the treatment and prevention of cholestasis-caused hepatopathy, particularly primary biliary cirrhosis and primary sclerosing cholangitis, and drugs for the treatment and prevention of obesity, fatty liver and steatohepatitis, containing as active ingredients benzothiazepine compounds having a thioamide bond and a quaternary ammonium substituent, represented by formula (1) below are provided. Also, drugs containing ileal bile acid transporter inhibiting compounds as active ingredients for the treatment and prevention of cholestasis-caused hepatopathy are provided.
Inventors:
Takehiko Sasahara
Mori Mori
Mori Mori
Application Number:
JP2004532766A
Publication Date:
July 07, 2010
Filing Date:
August 28, 2003
Export Citation:
Assignee:
Asahi Kasei Pharma Co., Ltd.
International Classes:
C07D281/10; A61K31/554; A61P1/16; A61P3/04; A61P3/06; A61P9/10; A61P43/00; C07D417/12; C07D487/08
Domestic Patent References:
| JP8506576A | ||||
| JP8507049A | ||||
| JP2002519418A | ||||
| JP2002500628A | ||||
| JP2002526627A |
Foreign References:
| WO2002008211A1 | ||||
| WO2002053548A1 | ||||
| WO2000061568A1 | ||||
| WO2000047568A1 |
Other References:
牧野 勲,特集・胆汁酸 胆汁酸代謝とその異常,クリニカ,日本,1990年,V17 N8,P477-482
Attorney, Agent or Firm:
Yoshikazu Iwase
Makoto Ono
Kenkyo Kanayama
Yasufumi Shiroyama
Makoto Ono
Kenkyo Kanayama
Yasufumi Shiroyama