Title:
新規キノロン５−（Ｎ−ヘテロ置換アミノ）抗微生物剤
Document Type and Number:
Japanese Patent JPH09512549
Kind Code:
A
Abstract:
The invention relates to antimicrobial 5-(N-heterosubstituted amino) quinolone compounds having a structure according to Formula (I) or (II): (I) (II) wherein (1) R1, R2, R3, R9 and R10 form any of a variety of quinolone and related heterocyclic structures similar to those known in the art to have antimicrobial activity; and (2) (a) R4 and R5 are, independently, hydrogen; lower alkyl; cycloalkyl; heteroalkyl; or -C(=O)-X-R8, where X is a covalent bond, N, O, or S, and R8 is lower alkyl, lower alkenyl, arylalkyl, a carbocylic ring, or a heterocyclic ring; or (b) R4 and R5 together comprise a heterocyclic ring that includes the nitrogen to which they are bonded; and the pharmaceutically-acceptable salts, biohydrolyzable esters, biohydrolyzable amides, and solvates thereof. The invention also relates to compositions comprising these compounds, as well as methods for treating infectious disorders using the compounds and/or compositions of the present invention.
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Inventors:
デムース，トーマス プロサー ジュニア．
ホワイト，ロナルド ユージン
ホワイト，ロナルド ユージン
Application Number:
JP52825595A
Publication Date:
December 16, 1997
Filing Date:
April 11, 1995
Export Citation:
Assignee:
ザ、プロクター、エンド、ギャンブル、カンパニー
International Classes:
A61K31/47; A61K31/4709; A61K31/495; A61K31/535; A61K31/54; A61P31/00; A61P31/04; C07D215/56; C07D401/04; C07D413/04; C07D471/04; C07D487/04; C07D487/08; C07D498/04; C07D498/06; C07D498/14; C07D498/16; C07D513/04; C07D513/06; C07D513/14; C07D513/16; C07D515/04; (IPC1-7): C07D215/56; A61K31/47; A61K31/495; A61K31/535; A61K31/54; C07D401/04; C07D471/04; C07D498/04; C07D498/14; C07D498/16; C07D513/04; C07D513/14; C07D513/16; C07D515/04
Attorney, Agent or Firm:
佐藤 一雄 （外３名）