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Title:
NEW REAGENT FOR PREPARING CAGED COMPOUND AND CAGING METHOD
Document Type and Number:
Japanese Patent JP2000319202
Kind Code:
A
Abstract:

To obtain a new compound having an N-succinimidyl aminocinnamate structure and enabling caged compounds useful for quantitatively measuring the concentration rise and fall of itself in a biosystem in a short time and also useful for observing succeeding various changes to be synthesized by a simple reaction.

This new compound is expressed by formula I [wherein X and Y are each H, a halogen or the like; R1 is H, a 1-4C alkyl or the like; R2 and R3 are each H, a 1-4C alkyl or the like and; Z is H or SO3M (wherein M is H, an alkali metal or an alkaline earth metal)] and is e.g. a compound of formula II. The compound of formula I is obtained by reacting 2- nitrobenzaldehyde with a Wittig reagent to form a cinnamate skeleton, by the hydrolysis of an ester group to form a carboxylic acid, by the condensation through dehydration of it with an N-hydroxysuccinimide to form an N- succipimidyl cinnamate and by reducing the nitro group substituent on the aromatic ring into an amino group.


Inventors:
SHIONO HIROBUMI
Application Number:
JP2000001714A
Publication Date:
November 21, 2000
Filing Date:
January 07, 2000
Export Citation:
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Assignee:
BUNSHI BIOPHOTONICS KENKYUSHO
International Classes:
C07D207/46; C07B43/00; C07B43/02; C07C229/44; (IPC1-7): C07B43/00; C07B43/02; C07C229/44; C07D207/46
Attorney, Agent or Firm:
Yoshiki Hasegawa (1 person outside)