To obtain the new subject compound which is an inhibitor for phosphodiesterases in the IV group and useful for therapeutic applications relating to inflammation and relaxation of bronchus, and asthma, chronic obliterative bronchitis, chronic articular rheumatism, etc.
This new substituted biphenyl or phenylpyridne compound is expressed by formula I [R1 is a 3-7C cycloalkyl, phenyl, naphthyl, etc.; R2 is a halogen, a straight or branched 1-6C alkyl, a 1-6C alkylcarbonyl, etc.; R3 is H, a straight or branched 1-6C alkyl, a 3-7C cycloalkyl, etc.; A is an O atom, a S atom, a (C=O) group, etc.; B ring is a phenyl or a pyridyl ring; X is an O atom, a S atom, etc.; Ra and Rb are each H, a halogen, a 1-6C alkyl, hydroxy, carboxy, etc.], or its steroisomer, etc., e.g. 2-hydroxy-3(3-nitrophenyl)-5- pyridylbenzaldehyde oxim is cited. The compound of formula I is prepared by using a compound of formula II as a starting material.
POISSONNET GUILLAUME
CANET EMMANUEL
LONCHAMPT MICHEL
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