Title:
NEW SUBSTITUTED N-FLUOROPYRIDINIUM SULFONATE, ITS PRODUCTION INTERMEDIATE AND THEIR PRODUCTION
Document Type and Number:
Japanese Patent JP3094677
Kind Code:
B2
Abstract:
PURPOSE: To obtain a new compound as a fluorinating agent having improved fluorinating efficiency and reaction selectivity, excellent in terms of yield of synthesis, reaction condition, handling and regeneration efficiency of fluorinating agent.
CONSTITUTION: A compound of formula I (R1 is H, halogen, 1-4C alkyl or haloalkyl; R2 is l-4C alkyl or haloalkyl) such as N-fluoro-4-methylpyridinium-2- sulfonate. The compound is obtained by reacting a pyridinesulfonic acid of formula III with fluorine molecule in the presence of an amine compound of formula II (R6 to R8 are H, 1-8C alkyl or aryl-substituted alkyl). By fluorinating 17β-acetoxy-3-trimethylsilyloxy-3,5-androstadiene with the fluorinating agent, the yield of useful 6-fluoro derivative and the ratio of the 6-fluoro derivative to 4-fluoro derivative are extremely enhanced.
Inventors:
Teruo Umemoto
Ginjiro Tomizawa
Ginjiro Tomizawa
Application Number:
JP20509492A
Publication Date:
October 03, 2000
Filing Date:
July 31, 1992
Export Citation:
Assignee:
Daikin Industries, Ltd.
International Classes:
C07B39/00; C07C49/167; C07D213/71; C07D213/89; C07J1/00; (IPC1-7): C07D213/89; C07C49/167; C07D213/71; C07J1/00
Domestic Patent References:
| JP2275859A | ||||
| JP399062A | ||||
| JP5125050A | ||||
| JP4235969A | ||||
| JP2231474A | ||||
| JP6310764A |
Attorney, Agent or Firm:
Aoyama Ryo (1 person outside)