Title:
NEW UREA DERIVATIVE, ITS PREPARATION AND ITS THERAPEUTIC APPLICATION
Document Type and Number:
Japanese Patent JPH05194359
Kind Code:
A
Abstract:
PURPOSE: To provide new compounds useful as acetylcholine esterase-inhibitors for curing myasthenia, memory disorders and dementia.
CONSTITUTION: The compounds of the formula I, e.g. 1-{2-[2-(N-benzyl-N- methylamino)ethoxy]ethyl}-3-(4-nitrophenyl)urea, are obtained by reading an amine of the formula II with the isocyanate denoted by the formula Ar-B-N=C =X in a solvent (e.g. dichloromethane), at a temp. from room temp. to the solvent-reflux temp. In the formula I, R1 is a 1-4C alkyl; R2 is a 5-7C cycoalkyl, cycloalkylmethyl, benzyl, etc.; A is O, methylene; (n) is 1 or 2; X is O, S; B is a direct bond, methylene, carbonyl; Ar is pyridyl, phenyl, oxofluorenyl, etc.
More Like This:
Inventors:
JIYANNRUI BIDARIYUKU
DENI BIGU
DENI BIGU
Application Number:
JP19700592A
Publication Date:
August 03, 1993
Filing Date:
July 23, 1992
Export Citation:
Assignee:
PF MEDICAMENT
International Classes:
C07C275/14; C07C275/24; C07C275/30; C07C275/54; C07C275/10; C07C335/04; C07C335/16; C07C335/18; C07D213/75; (IPC1-7): C07C275/10; C07C275/14; C07C275/54; C07C335/04
Attorney, Agent or Firm:
Hirose Shoichi
Previous Patent: JPS5194358
Next Patent: PREPARATION OF PURE N,N'-ASYMMETRICALLY SUBSTITUTED PHENYLUREAS
Next Patent: PREPARATION OF PURE N,N'-ASYMMETRICALLY SUBSTITUTED PHENYLUREAS