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Title:
純粋な5−HT6受容体アンタゴニストの新たな使用
Document Type and Number:
Japanese Patent JP6959371
Kind Code:
B2
Abstract:
The present invention relates to new uses of a pure 5-HT6 receptor antagonist, specifically 1-[(2-Bromophenyl)sulfonyl]-5-methoxy-3-[(4-methyl-1-piperazinyl)methyl]-1H-indole or a pharmaceutically acceptable salts thereof, for the treatment of dementia due to menopause, senile dementia, vascular dementia, chemotherapy-induced cognitive impairment and behavioral changes in dementia such as agitation, aggression, depression, anxiety, psychosis, disinhibition, or sleep disturbances. The present invention further provides use of the said compounds in the manufacture of medicament intended for the treatment of the disorders described herein.

Inventors:
Ramakrishna Nilogi
Venkata Lamarin Gaya Grandy
Pradeep Jayarajan
Venkateswir Justy
Application Number:
JP2019572134A
Publication Date:
November 02, 2021
Filing Date:
June 29, 2018
Export Citation:
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Assignee:
SUVEN LIFE SCIENCES LIMITED
International Classes:
A61K31/496; A61P25/16; A61P25/18; A61P25/20; A61P25/22; A61P25/24; A61P25/28; A61P43/00
Domestic Patent References:
JP2011506353A
Foreign References:
WO2016084956A1
Other References:
NIROGI, Ramakrishna et al.,The Journal of the Alzheimer's association,2009年07月01日,Vol. 5, No. 4,P2-264
BHYRAPUNENI, Gopinadh et al.,The Journal of the Alzheimer's association,2015年07月,Vol. 11, No. 7,P1-311
NIROGI, Ramakrishna et al.,The Journal of the Alzheimer's association,2011年07月,P3-451
NIROGI, Ramakrishna et al.,The Journal of the Alzheimer's association,Vol. 11, No. 7,2015年07月,P3-296
WILSON, C and TERRY, A. V. Jr.,Drugs of the Future,2009年12月,Vol. 34, No. 12,pp.969-975
Attorney, Agent or Firm:
Yasuhiko Murayama
Shinya Mitsuhiro
Tatsuhiko Abe