NEW MATERIAL: Compd. of formula I [wherein R1 is a 1-15C substd. alkyl, in particular a side chain of vitamin D2 (20-28C) or vitamin D3 (20-27C); Y is H, OH, etc.; X is a 1-6C alkyl, an arom. or a heterocyclic ring, etc.; R2 and R3 are H, or methyl but they are not methyl at the same time or both CH2 together].
EXAMPLE: 11α-(2-hemisuccinoyloxyethyl)-1,25,(OH)2-vitamin D3.
USE: Being useful for therapy of diseases caused by shortage or excess of vitamin D. In addition, being useful for labelling of radioisotopes for assays of metabolites of vitamin D and formation of enzyme-labelled tracers.
PROCESS: A compd. of formula II or formula III is reacted with formula IV (wherein R6 is a protective group for hydroxyl) in the presence of n-butyl lithium and then, elimination of protection is performed to obtain a compd. of formula I.
PIEERU JIYAN DOU KURERUKU
PIEERU ERIAARU
MOORI BANDOUWAARU
| JPS5387344A | 1978-08-01 | |||
| JPS5388316A | 1978-08-03 | |||
| JPS58193463A | 1983-11-11 | |||
| JPH02274A | 1990-01-05 |