NICOTINE IN THERAPEUTIC ANGIOGENESIS AND VASCULOGENESIS

Title:

NICOTINE IN THERAPEUTIC ANGIOGENESIS AND VASCULOGENESIS

Document Type and Number:

Japanese Patent JP2010043094

Kind Code:

A

Abstract:

To provide methods which can be used in therapeutic angiogenesis in, for example, treatment of ischemic syndromes such as coronary or peripheral arterial diseases by administration of nicotine or other nicotine receptor agonists.

The methods include administration of nicotine or other nicotine receptor agonists inducing angiogenesis in the inside of or the regions adjacent to ischemic tissues and administration of substances to synthesize nitrogen monoxide or enhance its activity or to synthesize prostacyclin or enhance its activity.

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Inventors:

COOKE JOHN
JANG JAMES
TSAO PHILLIP
HEESCHEN CHRISTOPHER

Application Number:

JP2009220049A

Publication Date:

February 25, 2010

Filing Date:

September 25, 2009

Export Citation:

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Assignee:

UNIV LELAND STANFORD JUNIOR

International Classes:

A61K31/465; C07D307/62; A61K31/122; A61K31/197; A61K31/198; A61K31/202; A61K31/355; A61K31/375; A61K31/44; A61K31/445; A61K31/525; A61K31/5575; A61K36/81; A61K38/00; A61K45/00; A61P7/02; A61P9/00; A61P9/10; A61P17/02; A61P27/06; A61P29/00; A61P35/00; A61P41/00; A61P43/00; C07D311/72; C07D401/04; C07D475/04

Domestic Patent References:

JPH06504041A	1994-05-12
JPH08143454A	1996-06-04
JPH09124593A	1997-05-13
JPH0641070A	1994-02-15

Foreign References:

WO1999010338A2

1999-03-04

Other References:

JPN6012029501; Ｎａｎｒｉ　Ｍ　ｅｔ　ａｌ．: 'ＧＴＳ-２１，　ａ　ｎｉｃｏｔｉｎｉｃ　ａｇｏｎｉｓｔ，　ａｔｔｅｎｕａｔｅｓ　ｍｕｌｔｉｐｌｅ　ｉｎｆａｒｃｔｉｏｎｓ　ａｎｄ　ｃｏｇｎｉｔｉｖｅ　ｄｅｆｉｃｉｔ　ｃａｕｓｅｄ　ｂｙ　ｐｅｒｍａｎｅ' Ｊｐｎ　Ｊ　Ｐｈａｒｍａｃｏｌ．Ｖｏｌ．７８　Ｎｏ．４, 199812, ｐｐ．４６３-４６９
JPN6012029502; Ｓｃｈｒｏｒ　Ｋ　ｅｔ　ａｌ．: 'Ａｕｇｍｅｎｔｅｄ　ｍｙｏｃａｒｄｉａｌ　ｉｓｃｈａｅｍｉａ　ｂｙ　ｎｉｃｏｔｉｎｅ--ｍｅｃｈａｎｉｓｍｓ　ａｎｄ　ｔｈｅｉｒ　ｐｏｓｓｉｂｌｅ　ｓｉｇｎｉｆｉｃａｎｃｅ．' Ｂｒ　Ｊ　Ｐｈａｒｍａｃｏｌ．Ｖｏｌ．１２５　Ｎｏ．１, 199809, ｐｐ．７９-８６
JPN6012029504; Ｓｉｌｖｅｒｓｔｅｉｎ　Ｐ．: 'Ｓｍｏｋｉｎｇ　ａｎｄ　ｗｏｕｎｄ　ｈｅａｌｉｎｇ．' Ａｍ　Ｊ　Ｍｅｄ．Ｖｏｌ．９３　ＮＯ．１Ａ．, 19920715, ｐｐ．２２Ｓ-２４Ｓ
JPN6012029506; Ｈｅｅｓｃｈｅｎ　Ｃ　ｅｔ　ａｌ．: 'Ｎｉｃｏｔｉｎｅ　ｓｔｉｍｕｌａｔｅｓ　ａｎｇｉｏｇｅｎｅｓｉｓ　ａｎｄ　ｐｒｏｍｏｔｅｓ　ｔｕｍｏｒ　ｇｒｏｗｔｈ　ａｎｄ　ａｔｈｅｒｏｓｃｌｅｒｏｓｉｓ．' Ｎａｔ　Ｍｅｄ．Ｖｏｌ．７　Ｎｏ．７, 200107, ｐｐ．８３３-８３９

Attorney, Agent or Firm:

Hatsushi Shimizu
Toshi Gobe
Koichi Niimi
Tomohiko Kobayashi
Shinichi Watanabe
Ryuichi Inoue

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