Title:
酸化窒素含有ジヒドロリポ酸及びその治療用途
Document Type and Number:
Japanese Patent JP2013507325
Kind Code:
A
Abstract:
Compounds are provided that comprise dinitroso-derivatives of dihydrolipoic acid. Pharmaceutical compositions comprising the compounds and methods of using the compounds for treating various diseases and disorders, including angina, hypertension, diabetes, dyslipidemia, renal insufficiency, myocardial infarction, stroke, atherosclerosis, and the target organ damage that accompanies these various diseases and disorders, are further provided. The compounds are useful in improving vasodilation, reducing low-density lipoprotein oxidation, and reducing inflammation in a subject.
Inventors:
Parta Salatay, Sampas
Application Number:
JP2011552969A
Publication Date:
March 04, 2013
Filing Date:
February 19, 2010
Export Citation:
Assignee:
Inv Ask Therapeutics Incorporated
International Classes:
C07C313/20; A61K31/20; A61K31/23; A61K31/36; A61K31/401; A61K31/445; A61P3/06; A61P3/10; A61P9/12; A61P13/12; A61P29/00; C07D207/16; C07D211/78; C07D317/64
Other References:
JPN6013049390; Ｐｅｔｉｔ， Ｃａｔｈｅｒｉｎｅ ｅｔ ａｌ．: 'Ｔｈｉｏｎｉｔｒｉｔｅｓ ａｓ ｐｏｔｅｎｔｉａｌ ｎｉｔｒｉｃ ｏｘｉｄｅ ｄｏｎｏｒｓ ａｓ ｅｘｅｍｐｌｉｆｉｅｄ ｂｙ Ｓ-ｎｉｔｒｏｓｏ- ａｎｄ Ｓ，Ｓ'-ｄｉｎｉｔｒｏｓｏｄｉｈｙｄｒｏ' Ｃｏｍｐｔｅｓ Ｒｅｎｄｕｓ ｄｅｓ Ｓｅａｎｃｅｓ ｄｅ ｌａ Ｓｏｃｉｅｔｅ ｄｅ Ｂｉｏｌｏｇｉｅ ｅｔ ｄｅ Ｓｅｓ Ｆｉｌｉａｌｅｓ １９０（５-６）, 1996, ６４１-６５０
JPN6013049391; Ｌｅ， Ｍｉｎ； Ｚｈａｎｇ， Ｈａｏ； Ｍｅａｎｓ， Ｇａｒｙ Ｅ．: 'Ｔｈｅ ｄｅｃｏｍｐｏｓｉｔｉｏｎ ｏｆ Ｓ-ｎｉｔｒｏｓａｔｅｄ ｄｉｔｈｉｏｌｓ： ａ ｍｏｄｅｌ ｆｏｒ ｖｉｃｉｎａｌ ｎｉｔｒｏｓｏｔｈｉｏｌｓ ｉｎ ｅｎｚｙｍｅｓ' Ｂｉｏｏｒｇａｎｉｃ ａｎｄ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ Ｌｅｔｔｅｒｓ ７（１１）, 1997, １３９３-１３９８
JPN6013049391; Ｌｅ， Ｍｉｎ； Ｚｈａｎｇ， Ｈａｏ； Ｍｅａｎｓ， Ｇａｒｙ Ｅ．: 'Ｔｈｅ ｄｅｃｏｍｐｏｓｉｔｉｏｎ ｏｆ Ｓ-ｎｉｔｒｏｓａｔｅｄ ｄｉｔｈｉｏｌｓ： ａ ｍｏｄｅｌ ｆｏｒ ｖｉｃｉｎａｌ ｎｉｔｒｏｓｏｔｈｉｏｌｓ ｉｎ ｅｎｚｙｍｅｓ' Ｂｉｏｏｒｇａｎｉｃ ａｎｄ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ Ｌｅｔｔｅｒｓ ７（１１）, 1997, １３９３-１３９８
Attorney, Agent or Firm:
Takao Hamano
Teruichi Hirai
Teruichi Hirai