NITRIC OXIDE-RELEASING PARTICLE FOR NITRIC OXIDE THERAPEUTICS AND BIOMEDICAL APPLICATION

Title:

NITRIC OXIDE-RELEASING PARTICLE FOR NITRIC OXIDE THERAPEUTICS AND BIOMEDICAL APPLICATION

Document Type and Number:

Japanese Patent JP2013006859

Kind Code:

A

Abstract:

To provide nitric oxide-releasing particles for delivering nitric oxide.

The invention relates to the nitric oxide-releasing particles comprising nitric oxide donors which are selected from diazeniumdiolate, nitrosamin, hydroxyl nitrosamine, nitrosothiol, hydroxylamine, hydroxyurea and a combination thereof, the nitric oxide-releasing particles for delivering nitric oxide, and their uses in biomedical and pharmaceutical applications. The particles are used for arterial stents, guide wires, catheters, trocar needles, bone anchors, bone screws, protective plates, hip and joint replacements, electrical leads, biosensors, probes, sutures, surgical drapes, wound dressings, and bandages.

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Inventors:

SCHOENFISCH MARK H
SHIN JAE
STASKO NATHAN

Application Number:

JP2012194895A

Publication Date:

January 10, 2013

Filing Date:

September 05, 2012

Export Citation:

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Assignee:

UNIV NORTH CAROLINA CHAPEL HILL

International Classes:

A61K33/00; A61K9/14; A61K9/70; A61K31/13; A61K31/133; A61K31/17; A61K31/655; A61K45/00; A61K47/02; A61K47/34; A61L15/00; A61L17/00; A61L27/00; A61L29/00; A61L31/00; A61P1/04; A61P11/00; A61P15/00; A61P29/00; A61P31/00; A61P35/00

Foreign References:

WO2004009253A1

2004-01-29

Other References:

JPN6012018713; ＮＯ　Ｒｅｌｅａｓｉｎｇ　Ｇｏｌｄ　Ｎａｎｏｐａｒｔｉｃｌｅｓ：　Ｓｙｎｔｈｅｓｉｓ　ａｎｄ　ＣｈａｒａｃｔｅｒｉｚａｔｉｏｎＣＡＰＬＵＳ［ＯＮＬＩＮＥ］, 2004, ＡＮ　２００４：９８２８２１
JPN6012018711; Ｊ　Ｂｉｏｍｅｄ　Ｍａｔｅｒ　Ｒｅｓｖｏｌ．３７，　ｎｏ．２, 1997, ｐ．１８２-９
JPN6012018709; Ａｎａｌ．　Ｃｈｅｍ．ｖｏｌ．７６, 2004, ｐ．４５４３-４５４９
JPN6012056744; Ａｄｖ．　Ｍａｔｅｒ．ｖｏｌ．１６，　ｎｏ．２１, 2004, ｐ．１９５９-１９６６
JPN6012056812; 日本外科学会雑誌ｖｏｌ．１０３, 2002, ｐ．１８４
JPN6012056747; Ｔｈｅ　Ｊｏｕｒｎａｌ　ｏｆ　Ｂｉｏｌｏｇｉｃａｌ　Ｃｈｅｍｉｓｔｒｙｖｏｌ．２７１，　ｎｏ．１１, 1996, ｐ．６１４４-６１５１
JPN6014037075; Ｊ　ＡＭ　ＣＨＥＭ　ＳＯＣｖｏｌ．１２５, 2003, ｐ．５０１５-５０２４
JPN6012018711; Ｊ　Ｂｉｏｍｅｄ　Ｍａｔｅｒ　Ｒｅｓｖｏｌ．３７，　ｎｏ．２, 1997, ｐ．１８２-９
JPN6012018709; Ａｎａｌ．　Ｃｈｅｍ．ｖｏｌ．７６, 2004, ｐ．４５４３-４５４９

Attorney, Agent or Firm:

Akira Shimoda
Kenichiro Akao
Kazuhiko Kurihara

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