Title:
多糖のニトロ誘導体
Document Type and Number:
Japanese Patent JP2004507587
Kind Code:
A
Abstract:
The present invention provides a new class of compounds presenting a high compatibility with tissues and organic fluids. Such new compounds are polysaccharides, essentially formed of units of uronic acid and/or hexosamine, containing nitro groups -ONO2 covalently bonded to the saccharide structure. Preferably, the polysaccharides according to the invention are prevalently of disaccharide repeating units formed of uronic acid and hexosamione. These compounds, in physiological conditions, selectively release NO, allowing a reduction in the amount of NO needed to achieve a determined therapeutical effect. This result has been achieved by functionalizing polysaccharides essentially formed of units of uronic acid and/or hexosamine, with substituents containing a -ONO2 group.
Inventors:
Francesica benedini
Benito Cass
Piero del Soldato
Paolo Grecel
Anna Maria Nagi
The Giantia Como Tori
Simona Venturini
Benito Cass
Piero del Soldato
Paolo Grecel
Anna Maria Nagi
The Giantia Como Tori
Simona Venturini
Application Number:
JP2002523963A
Publication Date:
March 11, 2004
Filing Date:
August 10, 2001
Export Citation:
Assignee:
Nicox Society Anonym
International Classes:
C07H3/04; A61K31/726; A61K31/727; A61P7/00; A61P9/00; C07H3/06; C07H5/06; C07H7/033; C07H11/02; C08B37/00; C08B37/06; C08B37/10; (IPC1-7): C08B37/00; A61K31/726; A61K31/727; A61P7/00; A61P9/00; C07H3/04; C07H3/06; C07H5/06; C07H7/033; C07H11/02; C08B37/10
Attorney, Agent or Firm:
Masatake Shiga
Tadashi Takahashi
Takashi Watanabe
Masakazu Aoyama
Suzuki Mitsuyoshi
Kazuya Nishi
Yasuhiko Murayama
Shinya Mitsuhiro
Tadashi Takahashi
Takashi Watanabe
Masakazu Aoyama
Suzuki Mitsuyoshi
Kazuya Nishi
Yasuhiko Murayama
Shinya Mitsuhiro