Title:
含窒素複素環化合物
Document Type and Number:
Japanese Patent JP4073961
Kind Code:
B2
Abstract:
The present invention provides nitrogen-containing heterocyclic compounds and pharmaceutically acceptable salts thereof which inhibit phosphorylation of PDGF receptor to hinder abnormal cell growth and cell wandering and thus are useful for the prevention or treatment of cell-proliferative diseases such as arteriosclerosis, vascular reobstruction, cancer and glomerulosclerosis. The compounds are represented by general formula (I): wherein V represents an oxygen atom or a sulfur atom; W represents 1,4-piperazinediyl or 1,4-homopiperazinediyl in which carbons on the ring may be substituted by unsubstituted alkyl groups; X represents a nitrogen atom or C-R<9>; Y represents a nitrogen atom or C-R<8>; Z represents a nitrogen atom or C-R<7> (provided that at least one of X, Y and Z represents a nitrogen atom); R<1> represents a hydrogen atom, a substituted or unsubstituted alkyl group, a substituted or unsubstituted alicyclic alkyl group, etc.; R<2> represents a substituted alkyl group, a substituted or unsubstituted alicyclic alkyl group, etc.; R<3>, R<4>, R<5> and R<6>, which may be the same or different, each represents a hydrogen atom, a halogen atom, a substituted or unsubstituted alkyl group, a nitro group, a cyano group, - OR<12>, -NR<15>R<16>, etc.; R<7> represents a halogen atom, etc.; R<8> has the same significance as R<7>, and R<9> represents a hydrogen atom or -COR<41>.
Inventors:
Kenji Matsuno
Toro Ichimura
Yuji Nomoto
Shigeki Fujiwara
Shinichi Ide
Tsukuda Eiji
Junko Irie
Shoji Oda
Toro Ichimura
Yuji Nomoto
Shigeki Fujiwara
Shinichi Ide
Tsukuda Eiji
Junko Irie
Shoji Oda
Application Number:
JP51638098A
Publication Date:
April 09, 2008
Filing Date:
October 01, 1997
Export Citation:
Assignee:
Kyowa Fermentation Industry Co., Ltd.
International Classes:
A61K31/496; A61K31/502; A61K31/517; A61K31/5377; A61K31/551; A61P9/00; A61P9/10; A61P13/00; A61P35/00; A61P43/00; C07D215/46; C07D217/22; C07D237/28; C07D237/34; C07D239/70; C07D239/94; C07D239/95; C07D401/12; C07D403/12; C07D405/12; C07D409/12; C07D417/12; C07D487/04; C07D491/056
Domestic Patent References:
| JP6247942A | ||||
| JP2167277A | ||||
| JP60120872A |
Other References:
ANDERSEN,K.E. et al., Oxadiazoles as bioisosteric transformations of carboxylic functionalities. II, European Journal of Medicinal Chemistry, 1996年, Vol.31, No.5, p.417-425
KOVALENKO,M. et al., Selective platelet-derived growth factor receptor kinase blockers reverse sis-transformation, Cancer Res., 1994年,Vol.54, No.23, p.6106-6114
KOVALENKO,M. et al., Selective platelet-derived growth factor receptor kinase blockers reverse sis-transformation, Cancer Res., 1994年,Vol.54, No.23, p.6106-6114