Title:
アミノ酸を結合したナイトロジェンマスタード誘導体及びその製造方法
Document Type and Number:
Japanese Patent JP3541037
Kind Code:
B2
Abstract:
Prodrugs, of generic formula I, are disclosed for use in antibody directed enzyme prodrug therapy (ADEPT). The prodrugs are substrates for carboxypeptidase G2 (CPG2) and yield more active cytotoxic drugs than known products of CPG2 catalysed reactions.
Inventors:
Burke, Philip, Jiyoung
Dowel, robert, iron
Mosier, Antony, Bryan
Sprinkler, Caroline, Jyoi
Dowel, robert, iron
Mosier, Antony, Bryan
Sprinkler, Caroline, Jyoi
Application Number:
JP50430994A
Publication Date:
July 07, 2004
Filing Date:
July 23, 1993
Export Citation:
Assignee:
Zeneca Limited
Canon Research Research Corporation Technology Limited
Canon Research Research Corporation Technology Limited
International Classes:
A61K31/17; A61K31/195; A61K31/27; A61K31/41; A61K39/395; A61K45/00; A61K47/48; A61P35/00; A61P43/00; C07C237/20; C07C237/40; C07C269/04; C07C271/54; C07C275/24; C07C275/40; C07C275/42; C07C309/66; C07C309/69; C07C309/72; C07C311/51; C07C317/50; C07C323/58; C07D257/04; (IPC1-7): C07C271/54; C07C275/40; C07C311/51; C07D257/04
Foreign References:
| WO1988007378A1 | ||||
| WO1990002729A1 |
Attorney, Agent or Firm:
Shigeru Yagida
Takao Hamano
Morita Tetsuji
Takao Hamano
Morita Tetsuji